Imaging Gray Matter with Concomitant Null Point Imaging from the Phase Sensitive Inversion Recovery Sequence
Imaging Gray Matter with Concomitant Null Point Imaging from the Phase Sensitive Inversion Recovery Sequence
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DOI：
10.1002/mrm.26061
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发表时间：
2016-11-01
影响因子：
3.3
通讯作者：
Gowland, Penny
中科院分区：
文献类型：
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作者：
Mougin, Olivier;Abdel-Fahim, Rasha;Gowland, Penny
目的：提出一种改进的三维（3D）叶间相敏反转恢复（PSIR）序列，包括伴随获得的新对比度，零点成像（NPI），以帮助检测和分类皮质灰质异常。方法：对11例多发性硬化症（MS）患者和9例对照者分别使用7 Tesla (T) MRI扫描仪和2例MS患者分别在0.6 mm各向同性分辨率下获得三维梯度回声PSIR图像。根据NPI/PSIR数据描绘皮层异常，然后根据在皮层中的位置进行分类。结果：与PSIR相比，NPI有助于检测皮质带内的皮质病变，其阳性对比增强。它还提供了改进的固有描绘带，增加了分类病变位置的信心。结论：提出的PSIR通过提供两个各向同性分辨率的t1加权3D数据集，包括显示皮层病变的NPI，清晰描绘灰质/白质边界和最小的部分体积效应，有助于皮质病变的分类。(C) 2015年作者。《医学磁共振》由Wiley期刊公司代表国际医学磁共振学会出版。
Purpose: To present an improved three-dimensional (3D) inter-leaved phase sensitive inversion recovery (PSIR) sequence including a concomitantly acquired new contrast, null point imaging (NPI), to help detect and classify abnormalities in cortical gray matter.Methods: The 3D gradient echo PSIR images were acquired at 0.6 mm isotropic resolution on 11 multiple sclerosis (MS) patients and 9 controls subjects using a 7 Tesla (T) MRI scanner, and 2 MS patients at 3T. Cortical abnormalities were delineated on the NPI/PSIR data and later classified according to position in the cortex.Results: The NPI helped detect cortical lesions within the cortical ribbon with increased, positive contrast compared with the PSIR. It also provided improved intrinsic delineation of the ribbon, increasing confidence in classifying the lesions' locations.Conclusion: The proposed PSIR facilitates the classification of cortical lesions by providing two T1-weighted 3D datasets with isotropic resolution, including the NPI showing cortical lesions with clear delineation of the gray/white matter boundary and minimal partial volume effects. (C) 2015 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.