Low expression of Bin1, along with high expression of IDO in tumor tissue and draining lymph nodes, are predictors of poor prognosis for esophageal squamous cell cancer patients
Low expression of Bin1, along with high expression of IDO in tumor tissue and draining lymph nodes, are predictors of poor prognosis for esophageal squamous cell cancer patients
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DOI：
10.1002/ijc.29481
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发表时间：
2015-09-01
影响因子：
6.4
通讯作者：
Liu, Lihua
中科院分区：
文献类型：
--
作者：
Jia, Yunlong;Wang, Hongyan;Liu, Lihua
吲哚胺2，3-双加氧酶(IDO)通过促进免疫逃逸参与了食管鳞癌(ESCC)的进展。已有研究表明桥接整合子-1(BIN1)通过抑制IDO的表达而抑制癌细胞生长，因此我们研究了BIN1和IDO的表达与ESCC患者预后的关系。采用流式细胞术、逆转录-聚合酶链式反应和免疫组织化学方法检测196例食管鳞癌标本。在肿瘤微环境(TME)和肿瘤引流淋巴结(TDLN)中，IDO高表达组CD3(+)CD4(+)T细胞、CD3(+)CD8(+)T细胞和CD3(-)CD16(+)CD56(+)NK细胞比例较低，而CD3(-)CD19(+)B细胞和CD4(+)CD25(+)Treg比例较高(P<0.05)。
Indoleamine 2,3-dioxygenase (IDO) has been reported to be involved in esophageal squamous cell cancer (ESCC) progression by promoting immune escape. Previous studies have revealed bridging integrator-1 (Bin1) can inhibit cancer cell growth by suppressing expression of IDO, thus we investigated the correlation between the expression of Bin1 and IDO and their prognostic significances for ESCC patients. Specimens were collected from 196 ESCC patients and detected with flow cytometry, reverse transcription-polymerase chain reaction and immunohistochemistry. We found that in tumor microenvironment (TME) and tumor draining lymph node (TDLN), the proportions of CD3(+)CD4(+) T cell, CD3(+)CD8(+) T cell and CD3(-)CD16(+)CD56(+)NK cell were lower while the proportions of CD3(-)CD19(+) B cell and CD4(+)CD25(+) Treg were higher in specimens with high IDO expression when compared to the specimens with low IDO expression (p