Monomeric Octahedral Ruthenium(II) Complex Enabled meta-C-H Nitration of Arenes with Removable Auxiliaries.
Monomeric Octahedral Ruthenium(II) Complex Enabled meta-C-H Nitration of Arenes with Removable Auxiliaries.
复制标题
DOI：
10.1021/acs.orglett.7b01297
复制
发表时间：
2017-06
期刊：
影响因子：
5.2
通讯作者：
Z. Fan;Jie Li;Heng Lu;Dong-Yu Wang;Chao Wang;M. Uchiyama;A. Zhang
中科院分区：
文献类型：
--
作者：
Z. Fan;Jie Li;Heng Lu;Dong-Yu Wang;Chao Wang;M. Uchiyama;A. Zhang
报道了一种可去除的肟辅助的芳烃间羟基硝化反应。机制研究和DFT计算表明，一种新的单体八面体钌（II）配合物负责元选择性硝化。作为助氧化剂的二氧是实现高转化率和高产率的关键。此外，临床中枢神经系统药物安定和氟伏沙明的后期修饰进一步展示了本反应方案的效用。
A removable oxime-assisted meta-C-H nitration of arenes is reported. Mechanistic investigations and DFT calculations reveal a new monomeric octahedral ruthenium(II) complex is responsible for the meta-selective nitration. Dioxygen as a cooxidant is crucial for achieving high conversion and good yields. Moreover, the utility of the present reaction protocol is further showcased by the late-stage modification of the clinical CNS drugs Diazepam and Fluvoxamine.