Cytomegalovirus and Toxoplasma Gondii Serostatus Prospectively Correlated With Problems in Self-Regulation but not Executive Function Among Older Adults.
Cytomegalovirus and Toxoplasma Gondii Serostatus Prospectively Correlated With Problems in Self-Regulation but not Executive Function Among Older Adults.
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DOI：
10.1097/psy.0000000000001086
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发表时间：
2022-06-01
影响因子：
3.3
通讯作者：
Karr, Justin E.
中科院分区：
文献类型：
--
作者：
Segerstrom, Suzanne C.;Reed, Rebecca G.;Karr, Justin E.
关键词：
巨细胞病毒（CMV）和弓形虫是可能感染大脑并产生认知和行为后果的生物体。我们假设这些潜伏感染与老年人的认知能力较差和自我调节问题有关。老年人（N = 138，法师= 75.5岁，59%为女性）有CMV和T。检测弓形虫血清状态、评估结晶智力（北美成人阅读测试）和执行功能（EF，例如，在每六个月进行一次的访问中评估自我调节（执行功能的行为调节量表-成人）（Mvisits = 16）。CMV+人群（79%）的自我调节能力显著低于CMV−人群（21%）（行为调节：γ = 0.108，95% CI [0.009，0.206];元认知：γ = 0.117，95% CI [0.005，0.229]），但智力或EF没有下降。T.弓形虫感染者（24%）与弓形虫感染者无显著性差异。弓形虫-人（76%）对任何结果。然而，T.弓形虫阳性男性比T.弓形虫-男性，女性则相反（行为调节相互作用γ = 0.267，95%CI [0.093，0.441]）。巨细胞病毒潜伏感染与更多的自我调节问题，这种差异的幅度是临床意义。T.弓形虫潜伏感染与更多问题有关，但仅限于女性。潜伏性感染可能与自我调节有关，但与EF无关，因为影响自我调节的因素，而不是神经心理测试的表现，如价值观和情绪。将潜伏感染与执行功能联系起来的努力可能在未来包括将这些功能应用于日常生活中的自我调节。
Cytomegalovirus (CMV) and Toxoplasma gondii are organisms that may infect the brain and have cognitive and behavioral consequences. We hypothesized that these latent infections would be prospectively associated with poorer cognition and more problems in self-regulation among older adults. Older adults (N = 138, Mage = 75.5 years, 59% women) had CMV and T. gondii serostatus tested, crystallized intelligence estimated (North American Adult Reading Test), and executive function (EF, e.g., Trail Making Test) and self-regulation (Behavior Regulation Inventory of Executive Function - Adult) assessed in visits occurring every six months (Mvisits = 16). CMV+ people (79%) had significantly poorer self-regulation vs. CMV− people (21%) (Behavioral Regulation: γ = 0.108, 95% CI [0.009,0.206]; Metacognition: γ = 0.117, 95% CI [0.005,0.229]), but not intelligence or EF. T. gondii+ people (24%) were not significantly different from T. gondii− people (76%) on any outcome. However, T. gondii+ men had better self-regulation vs. T. gondii− men, and the opposite was true of women (Behavioral Regulation interaction γ = 0.267, 95% CI [0.093, 0.441]). CMV latent infection was associated with more problems in self-regulation, and the magnitude of this difference was clinically significant. T. gondii latent infection was associated with more problems, but only for women. Latent infection might associate with self-regulation but not EF because of factors influencing self-regulation but not neuropsychological test performance, such as values and emotion. Efforts to link latent infection with executive functions might in future include the application of those functions to self-regulation in daily life.