Microwave-assisted FLP-catalyzed hydrogenations.
Microwave-assisted FLP-catalyzed hydrogenations.
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DOI：
10.1039/c5dt03857j
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发表时间：
2016-03
影响因子：
4
通讯作者：
Sebastian Tussing;Jan Paradies
中科院分区：
文献类型：
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作者：
Sebastian Tussing;Jan Paradies
采用微波辐射和常规加热对15种底物的FLP催化氢化进行了比较。直接比较表明，在微波的存在下，实现了高达2.5的速率加速。这种加热方法特别适用于含氮杂环的氢化。在温和的条件下和仅4巴的氢气压力下，以高产率非常有效地还原吖啶、奎宁和特别是1-甲基吲哚。
FLP-catalyzed hydrogenations of 15 substrates were compared using microwave irradiation and conventional heating. The direct comparison revealed that a rate acceleration of up to 2.5 was achieved in the presence of microwaves. This heating method is particularly promising for the hydrogenation of nitrogen-containing heterocycles. Acridine, quinines and especially 1-methyl indole were reduced very efficiently under mild conditions and only 4 bar hydrogen pressure in high yields.