Femtosecond laser-induced periodic nanostructure creation on PET surface for controlling of cell spreading
Femtosecond laser-induced periodic nanostructure creation on PET surface for controlling of cell spreading
复制标题
飞秒激光诱导在 PET 表面产生周期性纳米结构以控制细胞扩散
DOI：
10.1007/s00339-016-9716-4
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Takuya Kawa
中科院分区：
文献类型：
--
作者：
Yuji Sato;Masahiro Tsukamoto;Togo Shinonaga;Takuya Kawa
利用波长为1045 nm的飞秒激光，研究了在聚对苯二甲酸乙二醇酯（PET）表面周期性形成纳米结构的新方法。为了生成结构薄膜，将PET与硅（Si）片接触，然后用聚焦在硅（Si）片上的激光照射，穿过PET薄膜。为了评价表面形貌，原子力显微镜对处理和未处理的PET表面进行了分析。结果表明，激光处理在PET薄膜表面形成周期为600 nm、高度为100 nm的纳米结构。对具有和不具有周期性纳米结构的PET薄膜进行了细胞培养实验，结果表明：对于具有周期性纳米结构的PET薄膜，细胞（MG-63）沿周期性凹槽分布；相反，在未处理的PET膜上生长的培养物观察到随机细胞扩散。
A new method of periodic nanostructure formation on a polyethylene terephthalate (PET) surface has been developed, employing a femtosecond laser with a wavelength of 1045 nm. To generate structured films, the PET was placed in contact with a silicon (Si) wafer, followed by irradiation with the laser focused on the Si wafer, passing through the PET film. In order to evaluate the surface morphology, atomic force microscopy analysis was conducted on both treated and untreated PET surfaces. From the results, nanostructures with a period of 600 nm and height of 100 nm were formed on the PET film surface by laser treatment. A cell cultivation test was carried out on PET films with and without periodic nanostructures, showing that for nanostructured films, the cells (MG-63) were spread along the periodic grooves; in contrast, random cell spreading was observed for cultures grown on the untreated PET film.