A case-control study of childhood brain tumors and fathers' hobbies: a Children's Oncology Group study.
A case-control study of childhood brain tumors and fathers' hobbies: a Children's Oncology Group study.
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儿童脑肿瘤和父亲爱好的病例对照研究：儿童肿瘤学小组研究。
DOI：
10.1007/s10552-008-9189-7
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
Children'sOncologyGroup
中科院分区：
文献类型：
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作者：
Rosso,AndreaL;Hovinga,MaryE;Rorke-Adams,LucyB;Spector,LoganG;Bunin,GretaR;Children'sOncologyGroup
目的进行全面的病例对照研究，评估髓母细胞瘤（MB）和原始神经外胚层肿瘤（PNET）的父母危险因素。该分析旨在评估父亲的爱好与其孩子患 MB/PNET 的风险之间的关联。选择进行研究的爱好是那些与儿童癌症相关的职业具有相似暴露程度的爱好。方法病例包括 1991 年至 1997 年间诊断时年龄在 6 岁以下并在儿童癌症小组登记的 318 名受试者。通过随机数字拨号选择相同数量的对照，并分别与病例进行匹配。结果在多变量分析中，发现草坪护理与杀虫剂之间存在显着关联[怀孕期间：比值比 (OR) = 1.6，95% 置信区间 (CI)：1.0，2.5；出生后：OR = 1.8，95% CI：1.2，2.8] 与剥漆之间存在微弱关联[怀孕期间：OR = 1.4，95% CI：0.8，2.6；出生后：OR = 1.4，95% CI：0.7，2.6]。结论这项研究表明，家庭中的爱好（尤其是农药）接触可能会增加儿童患 MB/PNET 的风险；以前的研究大多局限于职业暴露。
ObjectiveA comprehensive case–control study was conducted to evaluate parental risk factors for medulloblastoma (MB) and primitive neuroectodermal tumor (PNET). This analysis was conducted to evaluate associations between fathers’ hobbies and risk of their children developing MB/PNET. The hobbies chosen for study were those with similar exposures as occupations associated with childhood cancers.MethodsCases were 318 subjects under six years of age at diagnosis between 1991 and 1997 and registered with the Children’s Cancer Group. An equal number of controls were selected through random digit dialing and individually matched to cases.ResultsIn multivariate analyses, a significant association was seen for lawn care with pesticides [during pregnancy: odds ratio (OR) = 1.6, 95% confidence interval (CI): 1.0, 2.5; after birth: OR = 1.8, 95% CI: 1.2, 2.8] and a weak association was seen for stripping paint [during pregnancy: OR = 1.4, 95% CI: 0.8, 2.6; after birth: OR = 1.4, 95% CI: 0.7, 2.6].ConclusionsThis study suggests that household exposures from hobbies, particularly pesticides, may increase risk of MB/PNET in children; previous research has been mostly limited to occupational exposures.