Urinary excretion of darbepoetin after intravenous vs subcutaneous administration to preterm neonates
Urinary excretion of darbepoetin after intravenous vs subcutaneous administration to preterm neonates
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DOI：
10.1038/sj.jp.7211596
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发表时间：
2006-10-01
影响因子：
2.9
通讯作者：
Christensen, R. D.
中科院分区：
文献类型：
--
作者：
Warwood, T. L.;Ohls, R. K.;Christensen, R. D.
目的：以往的研究表明，达贝泊丁在早产儿中皮下注射（s.c）比静脉注射（i.v）更有效地刺激红细胞生成。据推测，这是因为静脉给药后血浆浓度非常高导致尿中药物流失。然而，这一理论还没有经过系统的测试，也没有直接比较s.c.和静脉给药达贝泊丁对早产儿的影响。研究设计：如果早产的新生儿出生在
Objective: Previous studies suggest that darbepoetin might stimulate erythropoiesis in preterm neonates more effectively if injected subcutaneously (s.c.) than if infused intravenously (i.v.). It has been postulated that this is because very high plasma concentrations after i.v. dosing result in urinary loss of the drug. However, this theory has not been tested systematically, and no direct comparisons have been made between s.c. and i.v. dosing of darbepoetin in preterm neonates.Study design: Preterm neonates were eligible for this pilot study if they were born at