Recurrent Adaptation in RNA Interference Genes Across the Drosophila Phylogeny
Recurrent Adaptation in RNA Interference Genes Across the Drosophila Phylogeny
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DOI：
10.1093/molbev/msq284
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发表时间：
2011-02-01
影响因子：
10.7
通讯作者：
Kern, Andrew D.
中科院分区：
文献类型：
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作者：
Kolaczkowski, Bryan;Hupalo, Daniel N.;Kern, Andrew D.
RNA 干扰 (RNAi) 正在迅速成为果蝇和其他物种基因组组织、基因调控和免疫的重要组成部分。先前的研究表明，作为一个整体，参与 RNAi 的基因在果蝇中处于强烈的正向选择之下。在这里，我们描述了 23 个已知果蝇 RNAi 基因的适应性进化的程度和模式，这些基因包括果蝇内部和整个果蝇系统发育。我们发现大量 RNAi 基因反复出现蛋白质编码适应的有力证据，特别是那些涉及抗病毒免疫和转座因子防御的基因。我们将参与直接蛋白质-RNA相互作用的特定功能域确定为多个RNAi基因中反复适应的特定热点，这表明有针对性的共适应军备竞赛可能是RNAi进化的一般特征。我们的观察结果表明，进化军备竞赛场景产生的选择压力如何影响蛋白质相互作用网络和其他生化途径中的多个基因的预测模型。
RNA interference (RNAi) is quickly emerging as a vital component of genome organization, gene regulation, and immunity in Drosophila and other species. Previous studies have suggested that, as a whole, genes involved in RNAi are under intense positive selection in Drosophila melanogaster. Here, we characterize the extent and patterns of adaptive evolution in 23 known Drosophila RNAi genes, both within D. rnelanogaster and across the Drosophila phylogeny. We find strong evidence for recurrent protein-coding adaptation at a large number of RNAi genes, particularly those involved in antiviral immunity and defense against transposable elements. We identify specific functional domains involved in direct protein-RNA interactions as particular hotspots of recurrent adaptation in multiple RNAi genes, suggesting that targeted coadaptive arms races may be a general feature of RNAi evolution. Our observations suggest a predictive model of how selective pressures generated by evolutionary arms race scenarios may affect multiple genes across protein interaction networks and other biochemical pathways.