Alteration in the D-amino acid content of the rat pineal gland under anesthesia
Alteration in the D-amino acid content of the rat pineal gland under anesthesia
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DOI：
10.1007/bf01366926
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发表时间：
1999-01-01
期刊：
影响因子：
3.5
通讯作者：
Imai, K
中科院分区：
文献类型：
--
作者：
Hamase, K;Homma, H;Imai, K
在之前的一份报告(Hamase，K.等，Biochim BiPhys Acta 1134：214-222(1997))中，我们发现大鼠松果体含有D-亮氨酸(D-Leu)和D-天冬氨酸(D-Asp)。在本文中，我们报告了麻醉过程中这些D-氨基酸含量的变化。乙醚、氨基甲酸乙酯和戊巴比妥钠分别使D-Asp含量从2.8 nmol/松果体增加到5.0、4.8和5.8nmol/松果体。相比之下，乌拉坦或戊巴比妥钠可降低D-亮氨酸的含量。乌拉坦给药后4h，松果体D-亮氨酸含量由4.2pmol/松果体降至2.2pmol/松果体，但在给药1.5h后D-亮氨酸含量无明显变化。麻醉不影响这些氨基酸的L对映体的含量。氨基甲酸乙酯引起的D-亮氨酸含量下降几乎完全被β-激动剂(-)-异丙肾上腺素所抑制，而激动剂本身没有作用。
In a previous report (Hamase, K. et al., Biochim Biophys Acta 1134: 214-222 (1997)), we showed that the rat pineal gland contains D-leucine (D-Leu) as well as D-aspartic acid (D-Asp). In this communication we report alterations in the content of these D-amino acids during anesthesia. The D-Asp content was significantly increased from 2.8 to 5.0, 4.8 and 5.8 nmol/pineal gland by administration of ether, urethane and pentobarbital, respectively. In contrast, the D-Leu content was decreased by administration of urethane or pentobarbital. The D-Leu content decreased from 4.2 to 2.2 pmol/pineal gland 4 hours after administration of urethane, although the content remained unchanged until 1.5 hours after administration. The content of the L-enantiomers of these amino acids were not affected by anesthesia. The urethane-induced decrease in D-leucine content was almost completely suppressed by a beta-agonist, (-)-isoproterenol, whereas the agonist itself had no effect.