Immunogenicity of a Haemophilus influenzae type b vaccine in combination with diphtheria-pertussis-tetanus vaccine in infants.
Immunogenicity of a Haemophilus influenzae type b vaccine in combination with diphtheria-pertussis-tetanus vaccine in infants.
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b 型流感嗜血杆菌疫苗与白喉-百日咳-破伤风疫苗联合使用对婴儿的免疫原性。
DOI：
10.1093/infdis/148.3.530
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
J. Kuo
中科院分区：
文献类型：
--
作者：
J. Coulehan;C. Hallowell;R. Michaels;T. Welty;N. Lui;J. Kuo
78 名纳瓦霍婴儿（1 至 2 个月大）被随机分配到两个疫苗接种组之一：一组（40 名婴儿）计划接受三剂白喉-百日咳-破伤风（DPT）疫苗，另一组（38 名婴儿）接受 DPT 联合 B 型流感嗜血杆菌聚核糖核糖醇磷酸酯（DPT + PRP 疫苗）。在后一种疫苗中，百日咳抗原充当 PRP 的佐剂。 67 名婴儿（37 名接受 DPT 疫苗的婴儿和 30 名接受 DPT + PRP 疫苗的婴儿）完成了该方案。两组的局部和全身反应发生率相同。接受 DPT + PRP 疫苗的婴儿中，50% 在接种 3 剂后对 PRP 产生明确的抗体反应，13% 的婴儿可能产生反应。在接受百白破疫苗的婴儿中，分别有 14% 和 8% 有明确反应和可能反应；根据咽部培养结果，五分之三的有明确反应的婴儿感染了 b 型流感嗜血杆菌或交叉反应微生物。免疫反应似乎并未因母体抗体的存在而受到抑制。
Seventy-eight Navajo infants (one to two months of age) were randomly assigned to one of two vaccination groups: one group (40 infants) was scheduled to receive three doses of diphtheria-pertussis-tetanus (DPT) vaccine and the other (38 infants) to receive DPT combined with Haemophilus influenzae type b polyribosyl-ribitol phosphate (DPT + PRP vaccine). In the latter vaccine, pertussis antigen served as an adjuvant for PRP. Sixty-seven infants (37 who received DPT vaccine and 30 who received DPT + PRP vaccine) completed the protocol. Local and systemic reactions were equally frequent in the two groups. Fifty percent of the infants who received DPT + PRP vaccine had definite antibody responses to PRP after three doses, and 13% had possible responses. Of the infants who received DPT vaccine, 14% and 8% had definite and possible responses, respectively; three of five infants with definite responses were infected with H influenzae type b or cross-reacting organisms, as determined by pharyngeal cultures. The immune response did not appear to be suppressed by the presence of maternal antibody.