Malaria vaccines targeting the pre-erythrocytic stage: a scoping review
Malaria vaccines targeting the pre-erythrocytic stage: a scoping review
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针对红细胞前阶段的疟疾疫苗：范围审查
DOI：
10.12688/f1000research.24320.1
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Michael Walekhwa
中科院分区：
文献类型：
--
作者：
T. Ogeto;Ferdinand Ndubi;Mary Murithi;Richard Kagia;Esbon N Wambugu;Titus Suge;Carolyne Chepkirui;J. Tonui;Fiona C Maiyo;Lydia Momanyi;Michael Walekhwa
疟疾是一种致命的传染性寄生虫病，在全球造成严重的发病率和死亡率。尽管这是一个公共卫生问题，但预防这种疾病的有效疫苗仍然难以捉摸。全球正在努力探索开发和改进疫苗的可能方法，以对抗恶性疟原虫逃避免疫系统的复杂性。过去已经开发了一些针对寄生虫生命周期各个阶段的疫苗。传播阻断疫苗，如PpPf S25，针对蚊子载体中的寄生虫阶段。然而，这些群体疫苗只保护已免疫的人群。针对血液阶段形式的疫苗，如AMA-1和MSP-1疫苗，受到红细胞和分裂子复杂代谢途径的挑战。到目前为止，针对红细胞前孢子子阶段的疫苗仍然是最有希望的方法。在这里，我们系统地回顾了关于红细胞前期疫苗的文献和正在进行的工作。此外，我们强调了当前知识的差距，并指出了未来工作的潜在领域。从2010年开始，从谷歌scholar、PubMed和Cochrane获得了关于红细胞前疟疾疫苗的文章。评审了10篇论文。对一些疫苗进行了审查，重点是；疫苗类型、临床试验阶段、人口统计、疫苗免疫原性、有效性和安全性。据报道，RTS，S疫苗是最先进的，已经在一些疟疾流行的非洲国家进行了III期临床试验。讨论的红细胞前疫苗在临床试验中取得了里程碑式的进展。可能通过筛选新抗原、探索合适的疫苗施用载体以及使用联合多阶段疫苗方法来解决所引起的一些挑战。
Malaria is a deadly infectious parasitic disease that causes devastating morbidity and mortality globally. Despite being a public health concern, an effective vaccine for prevention of the disease remains elusive. Global efforts are exploring possible ways of developing and improving vaccines to counteract the complex nature in which Plasmodium falciparum evades the immune system. A number of vaccines have been developed in the past targeting the various parasitic life cycle stages. Transmission blocker vaccines, such as PpPf S25, target the parasite stages in the mosquito vector. However, these herd vaccines only protect the immunized population. Vaccines targeting blood-stage forms, such as the AMA-1 and MSP-1 vaccines, are challenged by the complex metabolic pathways of erythrocytes and merozoites. Vaccines targeting the pre-erythrocytic sporozoite stage remain the most promising approach thus far. Here, we systematically review the literature on pre-erythrocytic stage vaccines and on-going work in the field. Furthermore, we highlight gaps in current knowledge and point to potential areas of future work. Articles on pre-erythrocytic malaria vaccines were obtained from Google scholar, PubMed and Cochrane starting from the year 2010. Ten papers were reviewed. A number of vaccines were reviewed highlighting; the vaccine type, clinical phase of trial, population demographics, vaccine immunogenicity, efficacy and safety. The RTS,S vaccine is reportedly the most advanced, having been rolled out for phase III clinical trials in a number of malaria-endemic African countries. The pre-erythrocytic vaccines discussed have made milestones in clinical trials. Some of the challenges elicited may be addressed via screening for novel antigens, exploring suitable vaccine administration vehicles, as well as using a combined multi-stage vaccine approach.
影响因子：
15.9
作者：
Crompton, Peter D.;Pierce, Susan K.;Miller, Louis H.
通讯作者：
Miller, Louis H.