ASCENDING PROJECTIONS OF SUBSTANTIA NIGRA IN RAT
ASCENDING PROJECTIONS OF SUBSTANTIA NIGRA IN RAT
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DOI：
10.1002/cne.901320104
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发表时间：
1968-01-01
影响因子：
2.5
通讯作者：
CARMAN, JB
中科院分区：
文献类型：
--
作者：
FAULL, RLM;CARMAN, JB
用Nauta法研究了34只白化病大鼠中脑电解质损伤后的神经纤维变性。病变仅位于黑质（丘脑部，3例;网状部，8例;两部分，3例）;位于黑质及其周围结构（6例）;位于黑质的近尾侧（3例）、背尾侧（3例）、背侧（4例）和腹侧（1例）;以及位于半球和中脑外侧沿着电极轨迹（3例）。所有由电极对大脑和侧中脑的损伤引起的变性都是根据已知的纤维通路来解释的。病变涉及黑质（部网状和/或部延髓）与或不损害周围的结构产生细纤维变性，通过喙部和背侧囊的丘脑底核，转向背内侧，并进入腹外侧缘的腹内侧核丘脑（VM），在那里它终止。当黑质不参与时，这种黑质丘脑通路不会退化。累及上级小脑脚、红核或红核前放射的病变也可导致VM终末变性。然而，这个小脑红核丘脑通路，这是不中断的病变局限于黑质，进入VM的尾极的纤维。没有直接的黑质纹状体通路的证据。从小脑和黑质到VM的投射的演示确立了该核在大鼠中是灵长类动物丘脑腹前核和腹外侧核的同源物。
The Nauta method was used to study the fiber degeneration resulting from electrolytic lesions in the midbrain of 34 albino rats. Lesions were placed in the substantia nigra alone (pars compacta, 3; pars reticularis, 8; both parts, 3); in the substantia nigra and surrounding structures (6); immediately caudal (3), dorsocaudal (3), dorsal (4) and ventral (1) to the substantia nigra; and in the hemisphere and lateral midbrain along the track of the electrode (3). All the degeneration resulting from damage by the electrode to the cerebrum and lateral midbrain was accounted for in terms of known fiber pathways. Lesions involving the substantia nigra (pars reticularis and/or pars compacta) with or without damage to surrounding structures produced fine fiber degeneration which passed rostrally in the pars compacta and the dorsal capsule of the subthalamic nucleus, turned dorsomedially and entered the ventrolateral border of nucleus ventralis medialis thalami (VM) where it terminated. This nigrothalamic pathway did not degenerate when the nigra was not involved. Lesions involving the superior cerebellar peduncle, red nucleus or prerubral radiation also produced terminal degeneration in VM. However, the fibers of this cerebellorubro-thalamic pathway, which were not interrupted by lesions confined to the substantia nigra, entered the caudal pole of VM. There was no evidence of a direct nigrostriatal pathway. The demonstration of projections from the cerebellum and substantia nigra to VM establishes this nucleus as the homologue in the rat of nuclei ventralis anterior and ventralis lateralis thalami in primates.