Prenatal stress alters seizure thresholds and the development of kindled seizures in infant and adult rats
Prenatal stress alters seizure thresholds and the development of kindled seizures in infant and adult rats
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DOI：
10.1006/hbeh.2002.1839
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发表时间：
2002-12-01
影响因子：
3.5
通讯作者：
Burnham, WM
中科院分区：
文献类型：
--
作者：
Edwards, HE;Dortok, D;Burnham, WM
妊娠期和新生儿期的应激事件对后代日后的身心健康有重要影响。本研究采用海马点燃模型验证了出生前和/或出生后应激会影响幼年和成年大鼠癫痫发作易感性的假设。产前应激包括在妊娠早期或妊娠中期/晚期将母体每日束缚在强光下（45分钟，3次/天）。将幼崽与无应激母鼠所生的幼崽进行比较。产后应激（出生后第4天和第5天给药）包括与母体分离并置于陌生雄性动物的床上1小时或注射地塞米松。幼犬与同窝无应激的兄弟姐妹进行比较。早期和中期/晚期妊娠产前应激显着降低后放电阈值（ADT）在婴儿，14天大的大鼠后代，与非应激对照后代。这种对ADT的影响在成年后消失。妊娠中期/晚期应激增加了幼鼠及其成年雄性（而非雌性）同胞的点燃癫痫发作发生率。产后应激对ADT或点燃率无显著影响。这些研究结果表明，产前压力，特别是在怀孕的后半期，可能发挥重要作用，在未出生的后代癫痫发作的脆弱性增加。这些影响在婴儿期更为明显，但也可以延伸到成年期。(C)2002 Elsevier Science（美国）。
Stressful events during gestation and in the neonatal period have important effects on the later physical and mental health of the offspring. The present study tested the hypothesis that pre- and/or postnatal stress would affect seizure susceptibility in infant and adult rats, using the hippocampal kindling model. Prenatal stress consisted of daily restraint of the dam under bright light (for 45 min, 3 x / day) during either early gestation or mid/ late gestation. Pups were compared to pups born to unstressed dams. Postnatal stress (administered on Days 4 and 5 after birth) consisted of either separation from the dam and placement in the bedding of a strange male for 1 h or injection of dexamethasone. Pups were compared to nonstressed siblings of the same litter. Both early and mid/late-gestation prenatal stress significantly lowered the after-discharge threshold (ADT) in infant, 14-day-old rat offspring, as compared to nonstressed control offspring. This effect on ADT was lost by adulthood. Mid/late-gestation stress increased the rate of kindled seizure development in infant rats and in their adult male, but not female, siblings. Postnatal stress had no significant effect on ADT or kindling rate. These findings indicate that prenatal stress, particularly during the latter half of pregnancy, may play an important role in increasing seizure vulnerability in the unborn offspring. These effects are more pronounced in infancy, but can also extend to adulthood. (C) 2002 Elsevier Science (USA).