IPEADAM study: Indoor endotoxin exposure, family status, and some housing characteristics in English children
IPEADAM study: Indoor endotoxin exposure, family status, and some housing characteristics in English children
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DOI：
10.1016/j.jaci.2005.12.1311
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发表时间：
2006-03-01
影响因子：
14.2
通讯作者：
Niven, R
中科院分区：
文献类型：
--
作者：
Tavernier, G;Fletcher, G;Niven, R
背景资料：许多环境因素进行了调查，以确定他们参与的asthma epidemiology.Objective：我们试图调查的室内环境的英国children.Method：室内污染物，内毒素，过敏原，潮湿和哮喘在曼彻斯特（IPEADAM）研究招募了200名哮喘和年龄，性别和sibship大小匹配的非哮喘儿童后，一个基于社区筛查流行病学调查。对他们的住宅进行了几个室内空气因素的采样，并获得了水库灰尘样品。检测内毒素、Der p 1和湿重水平。管理了记录房屋特征的文件。室内环境污染物包括烟草烟雾、挥发性有机物、二氧化氮、甲醛、温度等。和相对湿度进行了研究。采用STATA单因素和多因素分析方法对两组儿童室内环境进行比较。（调整后的比值比，1.88; 95% CI，1.11-3.18; P = .018），生活在单亲家庭（调整后的比值比，3.89; 95% CI，1.25-12.1; P = 0.019），客厅重新装修（调整的比值比，3.15; 95% CI，1.36-7.33; P = 0.008），和自我报告的无潮湿（校正比值比，0.36，95%CI，0.14-0.91; P = 0.030）均为哮喘的独立预测因素。哮喘儿童和健康儿童在接触Der p 1、湿度客观测量、监护人吸烟习惯、宠物所有权、房屋类型或年龄、居住时间、中央供暖系统、绝缘类型、玻璃系统、地板类型、年龄和几种室内污染物的测量方面没有差异。IPEADAM研究表明，英国哮喘儿童和非哮喘儿童的室内环境差异很小。然而，一旦哮喘已经建立，内毒素的存在与哮喘儿童的客厅地毯水库灰尘呈正相关。临床意义：这项研究没有直接的临床意义，尽管它需要与流行病学环境中内毒素暴露的其他临床数据进行解释。
Background: Many environmental factors have been investigated to determine their involvement in the asthma epidemic.Objective: We sought to investigate the indoor environment of English children.Method: The Indoor Pollutants, Endotoxin, Allergens, Damp and Asthma in Manchester (IPEADAM) study recruited 200 asthmatic and age-, sex-, and sibship size-matched nonasthmatic children after a questionnaire-based community screening epidemiology survey. Their homes were sampled for several indoor air factors, and reservoir dust samples were obtained. Endotoxin, Der p 1, and dampness levels were assayed. Questionnaires were administered to record housing characteristics. Indoor pollutants, including environmental tobacco smoke, volatile organic compounds, nitrogen dioxide, formaldehyde, temperature., and relative humidity, were investigated. STATA univariate and multivariate analyses were used to compare the indoor environments of the children.Results: The levels of endotoxin (adjusted odds ratio, 1.88; 95% CI, 1.11-3.18; P = .018), living in a single-parent family (adjusted odds ratio, 3.89; 95% CI, 1.25-12.1; P = .019), redecoration in the living room (adjusted odds ratio, 3.15; 95% CI, 1.36-7.33; P = .008), and self-reported absence of dampness (adjusted odds ratio, 0.36; 95% CI, 0.14-0.91; P = .030) were all independent predictive factors of asthma. There was no difference between asthmatic and healthy children in their exposure to Der p 1, objective measurements of dampness, guardian's smoking habits, pet ownership, house type or age, time in residence, central heating systems, insulation types, glazing systems, floor types, and age and measurements of several indoor pollutants.Conclusion: The IPEADAM study has shown that there were very few differences in the indoor environments of English asthmatic and nonasthmatic children. However, once asthma has been established, the presence of endotoxin is positively associated with an asthmatic child's living room carpet reservoir dust. Clinical implications: There are no direct clinical implications of this research, although it needs interpreting with other clinical data on endotoxin exposure in epidemiologic settings.