Ultrastructural study of Sjögren's syndrome-like disease in MRL/l mice.
Ultrastructural study of Sjögren's syndrome-like disease in MRL/l mice.
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MRL/l 小鼠干燥综合征样疾病的超微结构研究。
DOI：
10.1111/j.1600-0714.1988.tb01316.x
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Gay,S
中科院分区：
文献类型：
--
作者：
Tanaka,A;O'Sullivan,FX;Koopman,WJ;Gay,S
对自身免疫性MRL/1小鼠的唾液腺进行了超微结构检查和免疫电子显微镜检查，以进一步表征这些动物中的干燥综合征样疾病。通过电子显微镜检查了12只雌性和7只雄性MRL/1、2只雌性MRL/n和1只雌性BALB/c小鼠的大唾液腺，并对4只雌性MRL/1小鼠的腺体进行了免疫电子显微镜检查，以检测Lyt-1和Lyt-2阳性淋巴细胞。BALE小鼠唾液腺未见单核细胞浸润，MRL/n小鼠唾液腺中也少见单核细胞浸润。然而，在MRL/1小鼠中，存在大量淋巴样细胞，腺泡细胞显示低细胞质密度、细胞质空泡化和细胞溶解。类淋巴细胞主要为Lyt-1阳性，但观察到一些Lyt-2阳性细胞。这些结果表明，MRL/1小鼠代表了一个有用的模型，用于研究干燥综合征在人类的发病机制。
Salivary glands of autoimmune MRL/1 mice were examined ultrastructurally and by immunoelectron microscopy to further characterize the Sjögren's syndrome‐like disease in these animals. Major salivary glands from 12 female and 7 male MRL/1, two female MRL/n, and one female BALB/c mice were examined by electron microscopy and the glands from 4 female MRL/1 mice were subjected to immunoelectron microscopy in order to detect Lyt‐1 and Lyt‐2 positive lymphoid cells. Mononuclear cell infiltrates were not seen in the salivary gland from the BALE mouse and occurred rarely in glands of MRL/n mice. However, in MRL/1 mice, numerous lymphoid cells were present and acinar cells displayed low cytoplasmic density, cytoplasmic vacuolization and cellular lysis. Lymphoid cells were predominantly Lyt‐1 positive although some Lyt‐2 positive cells were observed. These results suggest that the MRL/1 mouse represents a useful model for the study of the pathogenesis of Sjogren's syndrome in man.