Intra-operative touch preparation cytology following lumpectomy for breast cancer: A series of 400 procedures
Intra-operative touch preparation cytology following lumpectomy for breast cancer: A series of 400 procedures
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DOI：
10.1016/j.breast.2009.05.002
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发表时间：
2009-08-01
期刊：
影响因子：
3.9
通讯作者：
Leveque, Jean
中科院分区：
文献类型：
--
作者：
D'Halluin, Francois;Tas, Patrick;Leveque, Jean
目的：实现阴性切缘是乳腺癌保守治疗的关键。术中评估切缘的常规方法是大体或组织学检查冰冻切片。我们描述和评估的贡献，一个原始的术中触摸准备细胞学（IOTPC）技术（400程序）上进行396 patients.Materials和方法：IOTPC包括触摸载玻片的利益表面轻轻按下后，根据预定的条件采取的空间定位标本。结果：平均反应时间为10 min，这使得该技术与标准手术室程序兼容，其成本是合理的。该方法的敏感性为88.6%，特异性为92.2%，阳性预测值为73.6%，阴性预测值为97%，与石蜡切片组织学的相关性为91.5%。只有5真假阴性，发现在这一系列的技术，防止了11.75%的二次再切除程序阳性margins.Conclusion：IOTPC是一个可靠的临时方法评估手术切缘保守治疗乳腺癌和外科医生的有用工具。(C)2009爱思唯尔有限公司版权所有。
Aims: Achieving negative margins is essential in conservative treatment for breast cancer. The conventional method for intra-operative assessment of resection margins is gross or histological examination of frozen sections. We describe and evaluate the contribution of an original intra-operative touch preparation cytology (IOTPC) technique (400 procedures) performed on 396 patients.Materials and methods: IOTPC consists of touching glass slides to the surfaces of interest after gently pressing the spatially localized specimen taken according to predetermined conditions. The result is conveyed to the surgeon immediately and compared with the conventional histological findings after embedding in paraffin,Results: The average response time is 10 min, which renders the technique compatible with standard operating room procedures and its cost is reasonable. The method has a sensitivity of 88.6%, specificity of 92.2%, positive predictive value of 73.6%, negative predictive value of 97%, and correlation with paraffin section histology of 91.5%. Only 5 true false negatives were found in this series and the technique prevented 11.75% of secondary re-excision procedures for positive margins.Conclusion: IOTPC is a reliable extemporaneous method for assessing surgical margins in conservative treatment for breast cancer and a useful tool for surgeons. (C) 2009 Elsevier Ltd. All rights reserved.