Sleep and activity rhythms are related to circadian phase in the blind
Sleep and activity rhythms are related to circadian phase in the blind
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DOI：
10.1093/sleep/22.5.616
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发表时间：
1999-08-01
期刊：
影响因子：
5.6
通讯作者：
Arendt, J
中科院分区：
文献类型：
--
作者：
Lockley, SW;Skene, DJ;Arendt, J
研究目的：睡眠是由昼夜节律和自我平衡机制控制的。由于明暗周期是人类最重要的时间线索，盲人可能会出现昼夜节律紊乱，包括睡眠。该研究的目的是通过同时测量生物钟的内源性标志物6-硫酸氧褪黑激素（aMT 6s）来评估睡眠。设置和参与者：59名注册的盲人受试者在自己的家中进行研究。设计：受试者完成至少四周的每日睡眠和午睡日记，连续佩戴活动监测器，结果：昼夜节律紊乱最敏感的指标是白天小睡，而白天小睡则是昼夜节律紊乱最敏感的指标。正常夹带（NE）aMT 6s节律的受试者比异常夹带（AE）或自由奔跑（FR）受试者有更少的持续时间更短的午睡。这些小睡的时间不是随机的;在aMT 6s acrophase（phi（phi））之前和之后的5小时范围内发生的小睡明显多于该范围之外。AE受试者的夜间睡眠时间和持续时间障碍表现为永久性提前（提前睡眠期综合征，ASPS）或延迟（延迟睡眠期综合征，DSPS）。在FR受试者有短暂的进步和延迟的睡眠时间，增加夜间睡眠持续时间和减少白天小睡与正常aMT 6s phase.Conclusions：睡眠和活动节律的变化反映了昼夜节律的变化，aMT 6s定时。
Study objectives: Sleep is controlled by both circadian and homeostatic mechanisms. As the light-dark cycle is the most important time cue in humans, blind individuals may have circadian rhythm disorders including sleep. The aim of the study was to assess sleep with simultaneous measurement of an endogenous marker of the circadian clock, namely 6-sulphatoxymelatonin (aMT6s).Setting and participants: 59 registered blind subjects were studied in their own homes.Design: Subjects completed daily sleep and nap diaries for at least four weeks, wore activity monitors continuously, and collected urine samples over 48 hours each week for 3-5 weeks for assessment of aMT6s rhythms.Results: The most sensitive indicator of a circadian rhythm disorder was day-time napping. Subjects with normally entrained (NE) aMT6s rhythms had fewer naps of a shorter duration than abnormally entrained (AE) or free-running (FR) subjects. The timing of these naps was not random; significantly more naps occurred within a five-hour range before and after the aMT6s acrophase (phi (phi)) than outside this range. Disorders in the timing and duration of night sleep in AE subjects manifested as either a permanent advance (advanced sleep phase syndrome, ASPS) or delay (delayed sleep phase syndrome, DSPS). In FR subjects there were transient advances and delays in sleep timing that paralleled aMT6s timing with increased night sleep duration and reduced number and duration of day-time naps associated with a normal aMT6s phase.Conclusions: Changes in sleep and activity rhythms reflect changes in circadian phase.