LIPID-COMPOSITION OF BILE IN DIABETICS AND OBESITY-MATCHED CONTROLS
LIPID-COMPOSITION OF BILE IN DIABETICS AND OBESITY-MATCHED CONTROLS
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DOI：
10.1136/gut.20.6.518
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发表时间：
1979-01-01
期刊：
影响因子：
24.5
通讯作者：
HEATON, KW
中科院分区：
文献类型：
--
作者：
HABER, GB;HEATON, KW
将27例糖尿病患者的十二指肠胆汁与年龄、性别和体重指数相匹配的高热受试者的胆汁样本进行比较。胆固醇饱和度和胆汁酸、磷脂和胆固醇的摩尔百分比没有显著差异。两组的大部分胆汁样本都是过饱和的。成熟期糖尿病患者几乎都是肥胖者，他们的胆汁饱和程度高于较苗条的青少年患者。在对照组中，体脂和血浆甘油三酯水平均与胆汁胆固醇饱和度呈正相关，而在糖尿病组中则不相关。女性糖尿病患者的胆汁浓度低于对照组，这与胆汁排空受损是一致的。糖尿病患者中胆结石患病率的增加与其说是糖尿病本身的原因，不如说是经常与肥胖相关的原因。
Duodenal bile from 27 diabetes was compared with samples from heatlhy subjects matched for age, sex, and body mass index. Cholesterol saturation and the molar percentages of bile acids, phospholipids, and cholesterol were not significantly different. Most bile samples were supersaturated in both groups. The maturity onset diabetics who were almost all obese had more saturated bile than the slimmer juvenile onset patients. Body fatness and plasma triglyceride levels were both positively correlated with the cholesterol saturation of bile in the controls but not in the diabetics. Bile was less concentrated in female diabetics than in controls, which is consistent with impaired gallbladder emptying. The increased prevalence of gallstones in diabetics is due not so much to diabetes itself as to the frequently associated obesity.