Multi-scale modelling of biological systems in process algebra with multi-way synchronisation

Multi-scale modelling of biological systems in process algebra with multi-way synchronisation
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具有多路同步的过程代数生物系统的多尺度建模

DOI:
10.1145/2037509.2037537
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发表时间:
2011
期刊:
--
影响因子:
--
通讯作者:
Degasperi A
Degasperi A
中科院分区:
--
文献类型:
--
作者:
Degasperi A

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We present a stochastic process algebra designed for modelling biological systems at multiple scales, called process algebra with hooks (PAH). In PAH, processes represent different scales, e.g. biochemistry, cells or tissue. There are two synchronisation operators, distinguishing interactions within and between scales; composed actions represent events that occur at multiple scales. A stochastic semantics is provided, based on functional rates derived from kinetic laws. A parametric version of the algebra ensures that a model description is compact. An example illustrates how the algebra can be used to model and simulate multi-scale tissue growth, where growth and death of tissue depend on the local concentration of chemicals.
带有模式形成模型钩子的过程代数
DOI: 10.1016/j.entcs.2010.12.004
发表时间: 2010
期刊: Trans. Comp. Sys. Biology
影响因子: --
作者:
A. Degasperi;Muffy Calder
通讯作者: Muffy Calder
DOI: 10.1016/j.tcs.2009.02.037
发表时间: 2009-08-21
影响因子: 1.1
作者:
Ciocchetta, Federica;Hillston, Jane
通讯作者: Hillston, Jane