Genetic diversity of Legionella pneumophila inferred from rpoB and dotA sequences.
Genetic diversity of Legionella pneumophila inferred from rpoB and dotA sequences.
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从 rpoB 和 dotA 序列推断嗜肺军团菌的遗传多样性。
DOI：
10.1111/j.1469-0691.2005.01338.x
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Y. Kook
中科院分区：
文献类型：
--
作者：
K. Ko;H. Miyamoto;H. Lee;M. Park;K. Fukuda;B. Park;Y. Kook
本研究通过比较 267 个分离株（18 个参考株、149 个韩国分离株和 100 个日本分离株）的 rpoB (300-bp) 和 dotA (360-bp) 序列来表征嗜肺军团菌的种群结构。除了先前建立的六个克隆亚组之外，还确定了 P-V 至 P-VIII 四个亚组。发现基于 rpoB 和 dotA 序列的亚组与分离株的来源相关，该数据可能对未来的流行病学研究有用。十四个（五个韩国和九个日本）分离株在 rpoB 和 dotA 树中显示出不一致的亚群，这表明亚群之间甚至亚种之间的遗传交换可能在自然界中经常发生。
This study characterised the population structure of Legionella pneumophila by comparing the rpoB (300-bp) and dotA (360-bp) sequences of 267 isolates (18 reference strains, 149 Korean isolates and 100 Japanese isolates). In addition to the six clonal subgroups established previously, four subgroups, P-V to P-VIII, were identified. Subgroupings based on rpoB and dotA sequences were found to correlate with the source of the isolates, and this data may be useful for future epidemiological studies. Fourteen (five Korean and nine Japanese) isolates showed incongruent subgroupings in the rpoB and dotA trees, suggesting that genetic exchange among subgroups, and even among subspecies, may occur frequently in nature.