Protective Effects of Fucoxanthin against Alcoholic Liver Injury by Activation of Nrf2-Mediated Antioxidant Defense and Inhibition of TLR4-Mediated Inflammation
Protective Effects of Fucoxanthin against Alcoholic Liver Injury by Activation of Nrf2-Mediated Antioxidant Defense and Inhibition of TLR4-Mediated Inflammation
复制标题
岩藻黄质通过激活 Nrf2 介导的抗氧化防御和抑制 TLR4 介导的炎症对酒精性肝损伤的保护作用
DOI：
10.3390/md17100552
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发表时间：
2019-10-01
期刊：
影响因子：
5.4
通讯作者：
Yang，Zuisu
中科院分区：
文献类型：
--
作者：
Zheng，Jiawen;Tian，Xiaoxiao;Yang，Zuisu
岩藻黄素（Fx）是从海藻中提取的天然提取物，具有很强的抗氧化活性和多种其他生物活性作用。本研究阐明了Fx对酒精性肝损伤的保护机制。给药Fx可降低肝组织的病理影响，降低酒精引起的肝损伤的血清标志物浓度。Fx还能缓解氧化应激，降低肝组织中的氧化物水平和炎症。结果表明，Fx分别通过激活核因子-红细胞2相关因子2 （Nrf2）介导的信号通路和下调toll样受体4 （TLR4）介导的核因子-κB （NF-κB）信号通路的表达来减弱酒精诱导的氧化损伤和炎症反应。我们的研究结果表明，Fx可以作为一种潜在的营养保健品，在未来预防酒精性肝损伤。
Fucoxanthin (Fx) is a natural extract from marine seaweed that has strong antioxidant activity and a variety of other bioactive effects. This study elucidated the protective mechanism of Fx on alcoholic liver injury. Administration of Fx was associated with lower pathological effects in liver tissue and lower serum marker concentrations for liver damage induced by alcohol. Fx also alleviated oxidative stress, and lowered the level of oxides and inflammation in liver tissue. Results indicate that Fx attenuated alcohol-induced oxidative lesions and inflammatory responses by activating the nuclear factor erythrocyte-2-related factor 2 (Nrf2)-mediated signaling pathway and down-regulating the expression of the toll-like receptor 4 (TLR4)-mediated nuclear factor-kappa B (NF-κB) signaling pathway, respectively. Our findings suggest that Fx can be developed as a potential nutraceutical for preventing alcohol-induced liver injury in the future.