Diabetic dyslipidemia
Diabetic dyslipidemia
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DOI：
10.1016/j.ecl.2006.06.002
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发表时间：
2006-09-01
影响因子：
4.5
通讯作者：
Ginsberg, Henry N.
中科院分区：
文献类型：
--
作者：
Chahil, Tina J.;Ginsberg, Henry N.
2型糖尿病与心血管疾病风险显著增加相关。复杂的血脂异常是该人群潜在胰岛素抵抗的一个组成部分，是这种风险增加的关键。肝脏极低密度脂蛋白（VLDL）分泌增加是血脂异常的一个核心特征，并且与同时存在的高密度脂蛋白（HDL）降低和低密度脂蛋白（LDL）异常密切相关。有多种生理和药物方法可供使用，并且应该积极用于治疗糖尿病血脂异常。
Type 2 diabetes mellitus is associated with a markedly increased risk of cardiovascular disease. A complex dyslipidemia, which is an integral part of the underlying insulin resistance in this group, is a key to this increased risk. Increased secretion of VLDL from the liver is a central feature of dyslipidemia and is linked significantly to the low HDL and abnormal LDL that are also present. A number of physiologic and pharmacologic approaches are available and should be used aggressively to treat diabetic dyslipidemia.