Self-reported medication adherence and treatment satisfaction in patients with epilepsy
Self-reported medication adherence and treatment satisfaction in patients with epilepsy
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DOI：
10.1016/j.yebeh.2011.04.011
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发表时间：
2011-07-01
影响因子：
2.6
通讯作者：
Morisky, Donald E.
中科院分区：
文献类型：
--
作者：
Sweileh, Waleed M.;Ihbesheh, Manal S.;Morisky, Donald E.
目的：关于阿拉伯国家癫痫患者药物依从性和满意度的报道缺乏。本研究的目的是评估巴勒斯坦患者的药物依从性及其与治疗满意度、服用抗癫痫药物（aed）数量和癫痫控制之间的关系。方法：本横断面描述性研究于2010年夏季在巴勒斯坦纳布卢斯的Al-Makhfya政府门诊中心进行。在研究期间，采用方便抽样方法选择患者。药物依从性采用莫里斯基药物依从性量表（MMAS）进行测量；采用用药治疗满意度问卷（tsqm1.4）测量治疗满意度。如果患者在过去3个月内没有癫痫发作，则被任意定义为“控制良好”；如果患者在过去3个月内至少有一次癫痫发作，则被定义为“控制不良”。结果：研究了75例患者的方便样本。在MMAS的基础上，低依从率11例（14.7%），中等依从率37例（49.3%），高依从率27例（36%）。依从性与年龄（P = 0.02）、病程（P = 0.01）呈正相关。癫痫控制良好和控制不佳的患者在依从性方面没有显著差异。同样，单药治疗和多药治疗患者的依从性也没有显著差异。在有效性、副作用、便利性和总体满意度方面的平均满意度分别为73.6 +/- 20.7、82.4 +/- 29.8、69.5 +/- 15.5和68.4 +/- 18.3。两组疗效的平均值差异有统计学意义(P
Objective: Reports about medication adherence and satisfaction in patients with epilepsy in Arab countries are lacking. The objective of this study was to assess medication adherence and its relationship with treatment satisfaction, number of antiepileptic drugs (AEDs) taken, and epilepsy control in a sample of Palestinian patients.Methods: This cross-sectional descriptive study was carried out at Al-Makhfya Governmental Outpatient Center in Nablus, Palestine, during the summer of 2010. A convenience sampling method was used to select patients over the study period. Medication adherence was measured using the eight-item Morisky Medication Adherence Scale (MMAS); treatment satisfaction was measured using the Treatment Satisfaction Questionnaire for Medication (TSQM 1.4). Epilepsy was arbitrarily defined as "well controlled" if the patient had had no seizures in the last 3 months and was defined as "poorly controlled" if he or she had had at least one seizure in the last 3 months.Results: A convenience sample of 75 patients was studied. On the basis of the MMAS, 11 patients (14.7%) had a low rate, 37 (49.3%) had a medium rate, and 27 (36%) had a high rate of adherence. Adherence was positively and significantly correlated with age (P = 0.02) and duration of illness (P = 0.01). No significant difference in adherence was found between patients with well-controlled and those with poorly controlled epilepsy. Similarly, there was no significant difference in adherence between patients on monotherapy and those on polytherapy. Mean satisfaction with respect to effectiveness, side effects, convenience, and global satisfaction were 73.6 +/- 20.7, 82.4 +/- 29.8, 69.5 +/- 15.5, and 68.4 +/- 18.3, respectively. There were significant differences in mean values in the effectiveness (P