Partial correlation investigation on the default mode network involved in acupuncture: An fMRI study
Partial correlation investigation on the default mode network involved in acupuncture: An fMRI study
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针灸默认模式网络的偏相关研究：功能磁共振成像研究
DOI：
10.1016/j.neulet.2009.07.015
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发表时间：
2009-09-25
影响因子：
2.5
通讯作者：
Tian, Jie
中科院分区：
文献类型：
--
作者：
Liu, Peng;Zhang, Yi;Tian, Jie
一些临床报道和研究表明，针刺效应可以维持一段时间的刺激后状态，并调节默认模式网络（DMN）。本研究采用偏相关分析方法，探讨电针刺激大鼠左腿上的三个穴位（光明、昆仑、角心）和一个假穴是否对DMN有调制作用，以及如何改变DMN的内在连接性。结果表明，EAS后DMN会发生调制，并且四个点存在不同的调制模式。同时，我们发现后扣带皮层和楔前叶（PCC/pC）在刺激前后与其他节点有强烈的相互作用。PCC/pC与前扣带皮层（ACC）之间的相关性中断。眶前额叶皮层（OFC）与左内侧颞叶皮层（IMTC）在穴位处呈负相关。结果表明，针刺三个穴位和一个假穴对DMN的调制方式不同，这可能与针刺三个穴位和一个假穴引起的效应不同有关。(c)2009爱思唯尔爱尔兰有限公司保留所有权利。
Certain clinical reports and researches have shown that acupuncture effects can sustain a period during the post-stimulation state, and modulate the default mode network (DMN). In this study, partial correlation approach was utilized to investigate whether or not electro-acupuncture stimulation (EAS) at the three acupoints (GB37 (Guangming), BL60 (Kunlun) and KI8 (Jiaoxin)) and one sham point on the left leg modulated the DMN and how to change the intrinsic connectivity of the DMN. The results indicated that DMN could be modulated after EAS, and there existed different modulation patterns of the four points. Meanwhile, we found that the posterior cingulate cortex and precuneus (PCC/pC) strongly interacted with other nodes during the pre- and post-stimulation states. The correlation was interrupted between the PCC/pC and anterior cingulate cortex (ACC). The orbital prefrontal cortex (OFC) negatively interacted with the left medial temporal cortex (lMTC) at the acupoints. We suggested that the distinct modulation patterns to the DMN attributed to the different effects evoked by the three acupoints and one sham point. (c) 2009 Elsevier Ireland Ltd. All rights reserved.