Personal Memory Function in Mild Cognitive Impairment and Subjective Memory Complaints: Results from the Australian Imaging, Biomarkers, and Lifestyle (AIBL) Study of Ageing
Personal Memory Function in Mild Cognitive Impairment and Subjective Memory Complaints: Results from the Australian Imaging, Biomarkers, and Lifestyle (AIBL) Study of Ageing
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DOI：
10.3233/jad-131820
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发表时间：
2014-01-01
影响因子：
4
通讯作者：
Ellis, Kathryn A.
中科院分区：
文献类型：
--
作者：
Buckley, Rachel F.;Saling, Michael M.;Ellis, Kathryn A.
背景资料：自传体记忆（ABM）是指对个人经历的回忆，而个人语义记忆（PSM）是指与个人相关但共享的事实。轻度认知功能障碍（MCI）的诊断通常依赖于神经心理学测验，而这些测验并不涉及ABM和PSM领域。目的：我们的目的是描述认知健康（HC）记忆抱怨者、非记忆抱怨者和MCI参与者的ABM和PSM提取的性质，并探讨神经心理学测验与个人记忆之间的关系。性别和教育相匹配的参与者（HC=80和MCI=43）完成了情节ABM面试（EAMI）和电池的neuropsychological tests.Results：ABM和PSM没有不同的投诉人和非投诉人，但在MCI参与者较差，占年龄和抑郁症的发病率。MCI患者的个人记忆与客观记忆指标之间存在显著相关，但标准认知指标对MCI更为敏感。结论：MCI患者的个人记忆受损，表现为EAMI评分降低。记忆抱怨，目前的方法进行评估，并没有对个人记忆的影响。标准的主观问卷可能无法反映出引起临床关注的问题。了解老年人的个人记忆功能可能有助于发展一种更敏感的主观记忆问题的措施。
Background: Autobiographical memory (ABM) refers to the recollection of individual experiences, while personal semantic memory (PSM) refers to personally relevant, but shared, facts. Mild cognitive impairment (MCI) is routinely diagnosed with the aid of neuropsychological tests, which do not tap the ABM and PSM domains.Objective: We aimed to characterize the nature of ABM and PSM retrieval in cognitively healthy (HC) memory complainers, non-memory complainers, and MCI participants, and to investigate the relationship between neuropsychological tests and personal memory.Methods: Gender-and education-matched participants (HC=80 and MCI=43) completed the Episodic ABM Interview(EAMI) and a battery of neuropsychological tests.Results: ABM and PSM did not differ between complainers and non-complainers, but were poorer in MCI participants, after accounting for age and depressive symptomatology. There were significant associations between personal memory and objective memory measures were found in MCI participants, but standard cognitive measures were more sensitive to MCI.Conclusion: Personal memory was compromised in MCI, reflected by lower scores on the EAMI. Memory complaining, assessed by current approaches, did not have an impact on personal memory. Standard subjective questionnaires might not reflect the sorts of concerns that bring individuals to clinical attention. Understanding personal memory function in the elderly may aid in the development of a more sensitive measure of subjective memory concerns.