A genome-wide association study on adherence to low-carbohydrate diets in Japanese
A genome-wide association study on adherence to low-carbohydrate diets in Japanese
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关于日本人坚持低碳水化合物饮食的全基因组关联研究
DOI：
10.1038/s41430-022-01090-w
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发表时间：
2022
影响因子：
4.7
通讯作者：
et al.
中科院分区：
文献类型：
--
作者：
Nakamura Y;Tamura T;Narita Akira;et al.
背景/目的低碳水化合物饮食（LCD）对减轻体重是有用的，50-55%的碳水化合物摄入与最小风险相关。遗传差异与营养消费，食物偏好，和饮食模式，但是否在个人的特殊遗传差异影响LCD adherence is unknown.Subjects/methodsWe进行了一个GWAS坚持LCD利用14,076名参与者从日本多机构协作队列研究。我们使用先前验证的半定量食物频率问卷来估计食物消耗量。Halton等人的插补变量与LCD评分的相关性，我们使用线性回归分析，通过主成分分析调整性别、年龄、总膳食能量消耗和成分1至10。除了上述变量外，我们还对酒精消耗量（g/天）进行了调整，重复了分析。结果男性和女性在不调整酒精消耗量的情况下进行了合并分析;我们发现12号染色体上的395个变异与LCD评分相关，P值<5 × 10−8。在条件分析中加入12号染色体上rs671的剂量数据作为协变量，12号染色体上所有395个SNP的P值均不显著。在分析与额外的调整酒精消费，我们没有发现任何SNPs与LCD score.ConclusionWe发现rs671是负相关的坚持LCD，但酒精消费强烈混淆。
Background/objectivesLow-carbohydrate diets (LCD) are useful for weight reduction, and 50–55% carbohydrate consumption is associated with minimal risk. Genetic differences were related to nutritional consumption, food preferences, and dietary patterns, but whether particular genetic differences in individuals influence LCD adherence is unknown.Subjects/methodsWe conducted a GWAS on adherence to LCD utilizing 14,076 participants from the Japan Multi-Institutional Collaborative Cohort study. We used a previously validated semiquantitative food frequency questionnaire to estimate food consumption. Association of the imputed variants with the LCD score by Halton et al. we used linear regression analysis adjusting for sex, age, total dietary energy consumption, and components 1 to 10 by principal component analysis. We repeated the analysis with adjustment for alcohol consumption (g/day) in addition to the above-described variables.ResultsMen and women combined analysis without adjustment for alcohol consumption; we found 395 variants on chromosome 12 associated with the LCD score havingPvalues <5 × 10−8. A conditional analysis with the addition of the dosage data of rs671 on chromosome 12 as a covariate,Pvalues for all 395 SNPs on chromosome 12 turned out to be insignificant. In the analysis with additional adjustment for alcohol consumption, we did not identify any SNPs associated with the LCD score.ConclusionWe found rs671 was inversely associated with adherence to LCD, but that was strongly confounded by alcohol consumption.