Multiple mutations and cancer
Multiple mutations and cancer
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DOI：
10.1073/pnas.0334858100
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发表时间：
2003-02-04
影响因子：
11.1
通讯作者：
Anderson, JP
中科院分区：
文献类型：
--
作者：
Loeb, LA;Loeb, KR;Anderson, JP
大多数人类肿瘤是高度异质性的。我们假设这种异质性是由突变表型引起的。我们的前提是，正常的突变率不足以解释人类癌症中发现的多种突变，相反，癌症必须在其进化的早期表现出突变表型。在这里，我们研究的现状和影响的突变表型假说的预后，治疗和预防人类癌症。
Most human tumors are highly heterogenous. We have hypothesized that this heterogeneity results from a mutator phenotype. Our premise is that normal mutation rates are insufficient to account for the multiple mutations found in human cancers, and, instead, that cancers must exhibit a mutator phenotype early during their evolution. Here, we examine the current status and implications of the mutator phenotype hypothesis for the prognosis, treatment, and prevention of human cancers.