DBC1 promotes anoikis resistance of gastric cancer cells by regulating NF-κB activity
DBC1 promotes anoikis resistance of gastric cancer cells by regulating NF-κB activity
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DOI：
10.3892/or.2015.4007
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发表时间：
2015-08-01
期刊：
影响因子：
4.2
通讯作者：
Li, Guoxin
中科院分区：
文献类型：
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作者：
Huan, Yongwei;Wu, Deping;Li, Guoxin
乳腺癌中的β-淀粉样蛋白1（DBC 1）被认为是过度表达的，并作为几种人类癌症的预后不良指标。在这项研究中，我们检测了DBC 1在142个胃癌组织中的表达，通过免疫组织化学方法发现，DBC 1在胃癌中过表达，并与TNM分期和淋巴结转移显著相关。体外实验表明，DBC 1的表达与胃癌细胞的抗失巢凋亡能力相关，这已被定义为转移的关键。进一步研究表明，PKC 1通过IKK-β/NF-κ B信号通路调节胃癌细胞抗失巢凋亡的能力。综上所述，这些结果表明，DBC 1通过调节NF-κ B活性促进胃癌细胞的抗失巢凋亡，因此可能成为预防潜在转移的新的治疗靶点。
Deleted in breast cancer 1 (DBC1) has been known to be overexpressed and serves as a poor prognostic indicator of several human cancers. In this study, we examined DBC1 expression in a total of 142 gastric cancer tissues by immunohistochemistry and revealed that DBC1 was overexpressed in gastric cancer and significantly associated with TNM stage and lymph node metastasis. The in vitro experiments showed that DBC1 expression correlated with the ability of anoikis resistance in gastric cancer cells, which has been defined as critical to metastasis. Furthermore, the results showed that the IKK-beta/NF-kappa B signaling pathway was involved in the regulation of anoikis resistance by DBC1 in gastric cancer cells. Taken together, the results indicated that DBC1 promotes anoikis resistance in gastric cancer cells by regulating NF-kappa B activity and may thus be a new therapeutic target for preventing potential metastasis.