Cell Interplay in Osteoarthritis.
Cell Interplay in Osteoarthritis.
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DOI：
10.3389/fcell.2021.720477
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发表时间：
2021
影响因子：
5.5
通讯作者：
Bai L
中科院分区：
文献类型：
--
作者：
Li Z;Huang Z;Bai L
骨关节炎（OA）是一种常见的慢性疾病，是迫切需要解决的重大健康问题。骨性关节炎影响软骨和整个关节组织，包括软骨下骨、滑膜和髌下脂肪垫。这些组织的生理和病理变化影响OA的发生和发展。了解不同关节组织之间的复杂串扰及其在骨性关节炎发生和发展中的作用，对于阐明骨性关节炎的发病机制至关重要。在这篇综述中，我们首先概述了软骨细胞、滑膜细胞（滑膜成纤维细胞和巨噬细胞）、肥大细胞、成骨细胞、破骨细胞、各种干细胞和工程细胞（诱导多能干细胞）在OA发病中的作用。然后，我们讨论了这些细胞交流的各种机制，包括旁分泌信号，局部微环境，共培养，细胞外囊泡（外泌体）和细胞组织工程。我们特别关注干细胞来源的细胞外囊泡的治疗潜力和临床应用，它们作为细胞间通信的调节剂，在再生医学领域，如软骨修复。最后，讨论了基于外泌体治疗OA的挑战和局限性。这篇文章提供了一个全面的总结，关键细胞可能是未来治疗OA的目标。
Osteoarthritis (OA) is a common chronic disease and a significant health concern that needs to be urgently solved. OA affects the cartilage and entire joint tissues, including the subchondral bone, synovium, and infrapatellar fat pads. The physiological and pathological changes in these tissues affect the occurrence and development of OA. Understanding complex crosstalk among different joint tissues and their roles in OA initiation and progression is critical in elucidating the pathogenic mechanism of OA. In this review, we begin with an overview of the role of chondrocytes, synovial cells (synovial fibroblasts and macrophages), mast cells, osteoblasts, osteoclasts, various stem cells, and engineered cells (induced pluripotent stem cells) in OA pathogenesis. Then, we discuss the various mechanisms by which these cells communicate, including paracrine signaling, local microenvironment, co-culture, extracellular vesicles (exosomes), and cell tissue engineering. We particularly focus on the therapeutic potential and clinical applications of stem cell-derived extracellular vesicles, which serve as modulators of cell-to-cell communication, in the field of regenerative medicine, such as cartilage repair. Finally, the challenges and limitations related to exosome-based treatment for OA are discussed. This article provides a comprehensive summary of key cells that might be targets of future therapies for OA.
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影响因子：
7
作者：
Bannuru, R. R.;Osani, M. C.;McAlindon, T. E.
通讯作者：
McAlindon, T. E.
影响因子：
7
作者：
Buckley, C. T.;Vinardell, T.;Kelly, D. J.
通讯作者：
Kelly, D. J.
影响因子：
4.9
作者：
Abed É;Delalandre A;Lajeunesse D
通讯作者：
Lajeunesse D
影响因子：
--
作者：
Beekhuizen, Michiel;Bastiaansen-Jenniskens, Yvonne M.;van Osch, Gerjo J. V. M.
通讯作者：
van Osch, Gerjo J. V. M.
影响因子：
3.1
作者：
Behrends, D. A.;Cheng, L.;Martineau, P. A.
通讯作者：
Martineau, P. A.