NON-AGING DEVELOPMENTAL VARIANT OF CAENORHABDITIS-ELEGANS
NON-AGING DEVELOPMENTAL VARIANT OF CAENORHABDITIS-ELEGANS
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DOI：
10.1038/260523a0
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发表时间：
1976-01-01
期刊：
影响因子：
64.8
通讯作者：
HIRSH, D
中科院分区：
文献类型：
--
作者：
KLASS, M;HIRSH, D
一些生物天生就具有的自然现象可以延缓衰老速度，延长寿命，这有助于研究影响衰老速度的机制。这种现象存在于某些种类的线虫中。自由生活的土壤线虫的幼虫形式，秀丽隐杆线虫，具有进入半休眠，静止状态的能力，被称为dauer幼虫阶段（德语，“持久”幼虫）。初孵幼虫。elegansundergo四个幼虫阶段（L1-L4），由蜕皮打断。如果幼虫饥饿，它们将在第二次幼虫蜕皮时进入幼虫状态。此时，旧的角质层被一种特殊的，相对不渗透的角质层所取代，这是达乌尔幼虫所独有的。
THE study of mechanisms affecting the rate of ageing can be facilitated by naturally occurring phenomena, innate to some organisms, that enable the species to retard its ageing rate and extend its life span1. Such a phenomenon exists in certain species of nematode. Larval forms of the free-living soil nema-tode,Caenorhabditis elegans, possess the ability to enter a semi-dormant, quiescent state referred to as the dauer larval stage (German, “enduring” larva). Newly hatched larvae ofC. elegansundergo four larval stages (L1–L4) punctuated by moulting. If larvae are starved, they will enter the dauer state during the second larval moult. At this time, the old cuticle is replaced by a special, relatively impermeable cuticle unique to dauer larvae2.