Physical properties and functional alignment of soft-embalmed Thiel human cadaver when used as a simulator for ultrasound-guided regional anaesthesia
Physical properties and functional alignment of soft-embalmed Thiel human cadaver when used as a simulator for ultrasound-guided regional anaesthesia
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DOI：
10.1093/bja/aev548
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发表时间：
2016-05-01
影响因子：
9.8
通讯作者：
McLeod, G. A.
中科院分区：
文献类型：
--
作者：
Munirama, S.;Eisma, R.;McLeod, G. A.
背景资料：我们评估的物理特性和功能对齐的软防腐Thiel尸体如下：通过评估组织的可见性;通过测量其声学，机械和弹性性能;通过评估其耐久性，在重复注射;并通过调整图像与human.Methods：在四个软防腐Thiel尸体，我们进行了三个独立的研究。我们评估了以下因素：（i）防腐后28周内单个尸体的软组织可见性;（ii）单个尸体中1和5 ml肌间沟和股神经阻滞后组织的位移;（iii）两具尸体中神经和神经周围组织的硬度。我们将我们的发现与来自三名患者和一名志愿者的超声图像进行了比对。结果：防腐后2周和28周神经的可见性无显著性差异（几何平均值比1.13 [95%可信区间（CI）：0.75-1.68]，P=1.0）。尸体股骨和肌间沟组织块的平均组织位移相似[几何平均比1.02（95% CI：0.59-1.78），P=0.86]，1 ml和5 ml注射体积[几何平均比0.84（95% CI：0.70-1.01），P=0.19]。尸体的神经内硬度高于神经外硬度[杨氏模量;几何平均比3.05（95%CI：2.98-3.12），P
Background: We evaluated the physical properties and functional alignment of the soft-embalmed Thiel cadaver as follows: by assessing tissue visibility; by measuring its acoustic, mechanical and elastic properties; by evaluating its durability in response to repeated injection; and by aligning images with humans.Methods: In four soft-embalmed Thiel cadavers, we conducted three independent studies. We assessed the following factors: (i) soft tissue visibility in a single cadaver for 28 weeks after embalming; (ii) the displacement of tissues in response to 1 and 5 ml interscalene and femoral nerve blocks in a single cadaver; and (iii) the stiffness of nerves and perineural tissue in two cadavers. We aligned our findings with ultrasound images from three patients and one volunteer. Durability was qualified by assessing B-mode images from repetitive injections during supervised training.Results: Therewas no difference in visibility of nerves between 2 and 28 weeks after embalming {geometric mean ratio 1.13 [95% confidence interval (CI): 0.75-1.68], P=1.0}. Mean tissue displacement was similar for cadaver femoral and interscalene blocks [geometric mean ratio 1.02 (95% CI: 0.59-1.78), P=0.86], and for 1 and 5 ml injection volumes [geometric mean ratio 0.84 (95% CI: 0.70-1.01), P=0.19]. Cadavers had higher intraneural than extraneural stiffness [Young's modulus; geometric mean ratio 3.05 (95% CI: 2.98-3.12), P