Plasmodesmata mediate cell-to-cell transport of brassinosteroid hormones
Plasmodesmata mediate cell-to-cell transport of brassinosteroid hormones
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DOI：
10.1038/s41589-023-01346-x
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发表时间：
2023-06
影响因子：
14.8
通讯作者：
Yaowei Wang;Jessica Pérez-Sancho;M. Platre;B. Callebaut;M. Smokvarska;Karoll Ferrer;Yongming Luo;Trevor M. Nolan;Takeo Sato;Wolfgang Busch;P. Benfey;M. Kvasnica;Johan M. Winne;E. Bayer;Nemanja Vukašinović;E. Russinova
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文献类型：
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作者：
Yaowei Wang;Jessica Pérez-Sancho;M. Platre;B. Callebaut;M. Smokvarska;Karoll Ferrer;Yongming Luo;Trevor M. Nolan;Takeo Sato;Wolfgang Busch;P. Benfey;M. Kvasnica;Johan M. Winne;E. Bayer;Nemanja Vukašinović;E. Russinova
类甾醇（BRs）是植物生长、发育和适应环境胁迫所必需的甾体植物激素。BR以剂量依赖性方式起作用，并且不会长距离移动;因此，BR稳态维持对其功能至关重要。生物活性BR的生物合成依赖于激素前体的细胞间运动。然而，短距离BR运输的机制是未知的，其对内源性BR水平的控制的贡献仍然没有被探索。在这里，我们证明，胞间连丝（PD）介导相邻细胞之间的BR通道。细胞内BR含量反过来能够调节PD渗透性以优化其自身的流动性，从而操纵BR生物合成和信号传导。我们的工作揭示了一个迄今未知的类固醇运输模式在真核生物和暴露了一个额外的层BR的稳态调节植物。
Brassinosteroids (BRs) are steroidal phytohormones that are essential for plant growth, development and adaptation to environmental stresses. BRs act in a dose-dependent manner and do not travel over long distances; hence, BR homeostasis maintenance is critical for their function. Biosynthesis of bioactive BRs relies on the cell-to-cell movement of hormone precursors. However, the mechanism of the short-distance BR transport is unknown, and its contribution to the control of endogenous BR levels remains unexplored. Here we demonstrate that plasmodesmata (PD) mediate the passage of BRs between neighboring cells. Intracellular BR content, in turn, is capable of modulating PD permeability to optimize its own mobility, thereby manipulating BR biosynthesis and signaling. Our work uncovers a thus far unknown mode of steroid transport in eukaryotes and exposes an additional layer of BR homeostasis regulation in plants.