Direct neurotoxic effects of colchicine on cholinergic neurons in medial septum and striatum.
Direct neurotoxic effects of colchicine on cholinergic neurons in medial septum and striatum.
复制标题
秋水仙碱对内侧隔膜和纹状体胆碱能神经元的直接神经毒性作用。
DOI：
10.1016/0304-3940(88)90268-6
复制
发表时间：
1988
影响因子：
2.5
通讯作者：
McGinty,JF
中科院分区：
文献类型：
--
作者：
Peterson,GM;McGinty,JF
有丝分裂/微管抑制剂秋水仙碱已知对某些神经元群具有神经毒性。我们在此报道，单次脑室内注射秋水仙碱对胆碱能神经元产生特定的神经毒性作用，同时不影响内侧间隔核和纹状体中的 GABA 能神经元。据推测，秋水仙碱诱导的胆碱乙酰转移酶免疫反应性神经元的丧失代表由于神经营养因子的逆行轴浆运输破坏而导致的胆碱能神经元的退化。
The mitotic/microtubule inhibitor, colchicine, is known to be neurotoxic to certain populations of neurons. We report here that a single intraventricular injection of colchicine exerts specific neurotoxic effects on cholinergic neurons while sparing GABAergic neurons in the medial septal nucleus and striatum. It is hypothesized that the colchicine-induced loss of choline acetyltransferase immunoreactive neurons represents degeneration of the cholinergic neurons as a result of disruption of the retrograde axoplasmic transport of a neurotrophic factor.