Free cortisol awakening responses are influenced by awakening time
Free cortisol awakening responses are influenced by awakening time
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DOI：
10.1016/s0306-4530(03)00021-0
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发表时间：
2004-02-01
影响因子：
3.7
通讯作者：
Kirschbaum, C
中科院分区：
文献类型：
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作者：
Federenko, I;Wüst, S;Kirschbaum, C
对下丘脑-垂体-肾上腺（HPA）轴的心理生物学研究依赖于充分描述该系统活动的标记物。有证据表明，游离皮质醇对觉醒的反应，作为HPA轴的标志物，可以受到觉醒时间的影响。为了进一步研究这一可能的混杂因素，24名轮班工作的护士和31名正常睡眠-觉醒周期的女学生在觉醒后0、30、45和60分钟收集唾液样本。分别在早班（觉醒：0400-0530 h）、晚班（觉醒：0600-0900 h）和夜班（觉醒：1100-1400 h）的第1天和第2天对护士进行调查。学生们在连续两个工作日（觉醒：1845-2030 h）短暂午睡后进行了研究。在所有三种轮班条件下，觉醒后的平均皮质醇水平均显著升高（p
Psychobiological investigations on the hypothalamus-pituitary-adrenal (HPA) axis depend on markers that adequately describe the activity of this system. There is evidence that the free cortisol response to awakening, proposed as a marker for the HPA axis, can be influenced by time of awakening. To further investigate this possible confounder, 24 shift working nurses and 31 female students on a regular sleep-wake cycle collected saliva samples 0, 30, 45 and 60 minutes after awakening. Nurses were investigated on the first and second day of their early (awakening: 0400-0530 h), late (awakening: 0600-0900 h), and night shift (awakening: 1100-1400 h), respectively. Students were studied after taking a short nap on two consecutive weekdays (awakening: 1845-2030 h). Mean cortisol levels after awakening increased significantly under all three shift conditions (p