Clusters of Circulating Tumor Cells: a Biophysical and Technological Perspective.
Clusters of Circulating Tumor Cells: a Biophysical and Technological Perspective.
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DOI：
10.1016/j.cobme.2017.08.001
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发表时间：
2017-09
影响因子：
3.9
通讯作者：
Toner M
中科院分区：
文献类型：
--
作者：
Au SH;Edd J;Haber DA;Maheswaran S;Stott SL;Toner M
绝大多数与癌症相关的死亡是由转移引起的，然而其最有效的细胞驱动因素——循环肿瘤细胞群的行为，才刚刚开始被揭示出来。这篇综述强调了我们对肿瘤细胞簇的理解的最新进展，重点是使能技术。借助从患者血液中分离细胞簇的有前途的微流体策略，细胞簇之间细胞间粘附的重要性已经开始被揭示。由于它们的转移性，循环肿瘤细胞簇在癌症诊断、药物筛选、精确肿瘤学和抗转移治疗靶点方面的效用正在被探索。研究循环肿瘤细胞簇的工具的持续发展将增强我们对转移过程的基本理解，并可能有助于制定抑制和消除转移的新策略。
The vast majority of cancer associated deaths result from metastasis, yet the behaviors of its most potent cellular driver, circulating tumor cell clusters, are only beginning to be revealed. This review highlights recent advances to our understanding of tumor cell clusters with emphasis on enabling technologies. The importance of intercellular adhesions among cells in clusters have begun to be unraveled with the aid of promising microfluidic strategies for isolating clusters from patient blood. Due to their metastatic potency, the utility of circulating tumor cell clusters for cancer diagnosis, drug screening, precision oncology and as targets of antimetastatic therapeutics are being explored. The continued development of tools for exploring circulating tumor cell clusters will enhance our fundamental understanding of the metastatic process and may be instrumental in devising new strategies to suppress and eliminate metastasis.
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影响因子：
158.5
作者：
Cristofanilli, M;Budd, GT;Hayes, DF
通讯作者：
Hayes, DF
DOI：
10.1016/j.jtho.2016.06.017
发表时间：
2016-10
期刊：
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
影响因子：
--
作者：
Crosbie PA;Shah R;Krysiak P;Zhou C;Morris K;Tugwood J;Booton R;Blackhall F;Dive C
通讯作者：
Dive C
影响因子：
64.5
作者：
Cheung KJ;Gabrielson E;Werb Z;Ewald AJ
通讯作者：
Ewald AJ
影响因子：
8.4
作者：
FIDLER, IJ
通讯作者：
FIDLER, IJ
影响因子：
9.3
作者：
Harouaka, Ramdane A.;Zhou, Ming-Da;Zheng, Si-Yang
通讯作者：
Zheng, Si-Yang