Environmental genome of industrial products (EGIP): the missing link for human health
Environmental genome of industrial products (EGIP): the missing link for human health
复制标题
工业产品环境基因组（EGIP）：人类健康缺失的一环
DOI：
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
M. Overcash
中科院分区：
文献类型：
--
作者：
M. Overcash
人类健康的影响来自遗传因素和环境。人类健康的影响，作为先天与后天（遗传与非共享化学环境），目前在基因组学中仅以人类基因组（双螺旋）表示。非共有化学品环境（环境）成分的基因组结构的发现填补了一个概念空白，从而使人们更全面地了解对人类健康的总体影响。工业产品的环境基因组在绘制之后，将成为在地方和全球一级评估广泛和集中的健康影响（人类和生态）的全球框架。因此，为社会提供的产品具有双重效益和影响。环境基因组是金字塔形的，而不是螺旋形的。EGIP的形状是x = ny，其中n是结构构建单元（SBU），其对于100 000种化学品中的每一种都是不同的，x是制造产品的工业生态系统的复杂性（基因组的宽度），y是从自然资源到产品的水平或阶段（基因组的长度）。 环境基因组的信息量（5 - 80亿个片段）与人类基因组（30亿个化学对）大致相同。金字塔形的环境基因组片段从自然资源（包含元素周期表的大部分）到商业中的最终化学/材料产品，其中大约有100 000种产品构成了所有产品。 总而言之，“人类基因组在创造我们每个人时都令人敬畏。工业产品的环境基因组必须得到尊重，因为它是我们人类真正创造的。
Human health impacts come from genetic factors and from the environment. Human health impacts, as nature versus nurture (genetic versus non-shared chemical environmental), have currently been represented in genomics only as the human genome (double helix). The discovery of the genomic structure for the non-shared chemical environmental (the environment) component fills a conceptual gap and thus provides a more complete understanding of total impact on human health. When mapped, the environmental genome of industrial products (EGIP) would serve as a global framework for assessing broad and clustered health effects (human and ecological) at the local and global levels. Thus products for society have coupled benefits and impacts. The environmental genome is pyramidal rather than helical. The shape of the EGIP is, x = ny, where n is a structural building unit (SBU) which is different for each of the 100 000 chemicals, x is the complexity of the industrial ecosystem to make the product (width of genome), and y is the levels or stages from natural resources to product (length of genome). The environmental genome is approximately the same informational size (0.5–8 billion pieces) as the human genome (3 billion chemical pairs). The pyramidal environmental genomic pieces span from natural resources (containing much of the Periodic Table) to the final chemical/material products in commerce of which there are about 100 000 which comprise all products. In summary, “the human genome is held in awe as it created each of us. The environmental genome of industrial products must be respected for it is what we as humans have truly created.”
影响因子：
158.5
作者：
Lichtenstein, P;Holm, NV;Hemminki, K
通讯作者：
Hemminki, K
影响因子：
10.4
作者：
Weaver VM;Buckley TJ;Groopman JD
通讯作者：
Groopman JD