INCIDENCE OF EPILEPSY AND UNPROVOKED SEIZURES IN ROCHESTER, MINNESOTA - 1935-1984
INCIDENCE OF EPILEPSY AND UNPROVOKED SEIZURES IN ROCHESTER, MINNESOTA - 1935-1984
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DOI：
10.1111/j.1528-1157.1993.tb02586.x
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发表时间：
1993-05-01
期刊：
影响因子：
5.6
通讯作者：
KURLAND, LT
中科院分区：
文献类型：
--
作者：
HAUSER, WA;ANNEGERS, JF;KURLAND, LT
从1935年到1984年，确定了美国明尼苏达州罗切斯特居民癫痫和所有无端癫痫发作的发病率。癫痫的经神经病学校正的发病率为44/100，000人年。男性的发病率明显高于女性，在出生后第一年发病率较高，但在75岁以上或等于75岁的人群中发病率最高。60%的新病例表现为部分性癫痫发作，三分之二的病例没有明确的前因。脑血管疾病是最常见的前因，占病例的11%。在8%的病例中观察到的出生神经缺陷、智力迟钝和/或脑瘫是第二常见的既存疾病。74岁时癫痫的累积发病率为3.1%。年龄调整后的所有无端癫痫发作的发病率为每10万人年61例。年龄和性别特异性发病率趋势与癫痫相似，但较高比例的病例病因不明，特征为全身性发作癫痫发作。所有无端癫痫发作的累积发生率为4.1%，直到74岁。随着时间的推移，癫痫和无端癫痫发作的发生率在儿童中减少，在老年人中增加。
The incidence of epilepsy and of all unprovoked seizures was determined for residents of Rochester, Minnesota U.S.A. from 1935 through 1984. Age-adjusted incidence of epilepsy was 44 per 100,000 person-years. Incidence in males was significantly higher than in females and was high in the first year of life but highest in persons aged greater-than-or-equal-to 75 years. Sixty percent of new cases had epilepsy manifested by partial seizures, and two thirds had no clearly identified antecedent. Cerebrovascular disease was the most commonty identified antecedent, accounting for 11% of cases. Neurologic deficits from birth, mental retardation and/or cerebral palsy, observed in 8% of cases, was the next most frequently identified preexisting condition. The cumulative incidence of epilepsy through age 74 years was 3.1%. The age-adjusted incidence of all unprovoked seizures was 61 per 100,000 person-years. Age- and gender-specific incidence trends were similar to those of epilepsy, but a higher proportion of cases was of unknown etiology and was characterized by generalized onset seizures. The cumulative incidence of all unprovoked seizures was 4.1% through age 74 years. With time, the incidence of epilepsy and of unprovoked seizures decreased in children and increased in the elderly.