Night Shift Work and Hormone Levels in Women
Night Shift Work and Hormone Levels in Women
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DOI：
10.1158/1055-9965.epi-11-1128
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发表时间：
2012-04-01
影响因子：
3.8
通讯作者：
Stanczyk, Frank Z.
中科院分区：
文献类型：
--
作者：
Davis, Scott;Mirick, Dana K.;Stanczyk, Frank Z.
背景：夜班工作会扰乱夜间褪黑激素的正常分泌，可能通过增加生殖激素水平导致乳腺癌风险增加。我们调查了夜班工作是否与尿6-亚硫氧褪黑激素（褪黑激素的主要代谢物）水平下降和尿生殖激素水平升高有关。方法：研究对象为年龄20 ~ 49岁、月经周期正常的夜班护士172名、白班护士151名。在工作和睡眠期间收集尿液样本，检测6-亚甲氧基褪黑激素、促黄体生成素（LH）、促卵泡激素（FSH）和雌酮偶联物（E1C）。结果：与白班女性相比，夜班女性白天睡眠时6-亚甲氧基褪黑素水平降低62%，FSH和LH水平分别升高62%和58% (P
Background: Night shift work may disrupt the normal nocturnal rise in melatonin, resulting in increased breast cancer risk, possibly through increased reproductive hormone levels. We investigated whether night shift work is associated with decreased levels of urinary 6-sulfatoxymelatonin, the primary metabolite of melatonin, and increased urinary reproductive hormone levels.Methods: Participants were 172 night shift and 151 day shift-working nurses, aged 20-49 years, with regular menstrual cycles. Urine samples were collected throughout work and sleep periods and assayed for 6-sulfatoxymelatonin, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and estrone conjugate (E1C).Results: 6-Sulfatoxymelatonin levels were 62% lower and FSH and LH were 62% and 58% higher, respectively, in night shift-working women during daytime sleep than in day shift-working women during nighttime sleep (P