Facile two-step synthesis of 2-arylbenzofurans based on the selective cross McMurry couplings
Facile two-step synthesis of 2-arylbenzofurans based on the selective cross McMurry couplings
复制标题
基于选择性交叉 McMurry 偶联的 2-芳基苯并呋喃的简便两步合成
DOI：
10.1021/jo7019652
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发表时间：
2007-12-21
影响因子：
3.6
通讯作者：
Zi, Guo-Fu
中科院分区：
文献类型：
--
作者：
Duan, Xin-Fang;Zeng, Jing;Zi, Guo-Fu
[图表]开发了一种新的2-芳基苯并呋喃的两步合成方法。它涉及水杨醛或取代水杨醛与芳香醛的选择性交叉McMurry偶联和所得邻乙烯基酚的顺序氧化环化。利用该合成方法，已经有效地合成了包括cicerfuran（5）在内的多种2-芳基苯并呋喃。
[GRAPHICS]A novel two-step synthesis of 2-arylbenzofurans has been developed. It involves a selective cross McMurry coupling of a salicylaldehyde or substituted salicylaldehyde with an aromatic aldehyde and a sequential oxidative cyclization of the resulting ortho-vinylphenols. Utilizing this synthetic protocol, a variety of 2-arylbenzofurans including cicerfuran (5) have been efficiently synthesized.