Cancer-related issues of CD147.
Cancer-related issues of CD147.
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DOI：
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发表时间：
2010-05
影响因子：
2.5
通讯作者：
U. Weidle;W. Scheuer;Daniela Eggle;S. Klostermann;H. Stockinger
中科院分区：
文献类型：
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作者：
U. Weidle;W. Scheuer;Daniela Eggle;S. Klostermann;H. Stockinger
CD 147参与许多生理功能，如淋巴细胞反应性、精子发生、着床、受精和发育早期的神经功能。在这里，我们特别回顾了CD 147在癌症中的作用。本文主要从以下几个方面对CD 147在恶性肿瘤和正常组织中的表达及其对预后的影响、肿瘤细胞表达的CD 147与间质细胞的相互作用、基质金属蛋白酶的诱导以及CD 147在肿瘤血管生成中的作用进行了综述。CD 147在与单羧酸转运蛋白（MCT）和氨基酸转运蛋白，如CD 98 hc和大中性氨基酸转运蛋白1（LAT 1）的超复合物中的功能，以及CD 147在与小窝蛋白-1和整联蛋白复合物中的功能贡献，进行了讨论。总结了利用CD 147定向RNAi和单克隆抗体进行的靶标验证实验。最后，讨论了CD 147作为癌症患者治疗干预靶点的相关性。
CD147 is involved in many physiological functions, such as lymphocyte responsiveness, spermatogenesis, implantation, fertilization and neurological functions at early stages of development. Here we specifically review the role of CD147 in cancer. We focus on the following aspects: expression of CD147 in malignant versus normal tissues and its possible impact on prognosis, interaction of tumor cell-expressed CD147 with stroma cells and induction of matrix metalloproteinases, as well as the role of CD147 in tumor angiogenesis. The function of CD147 in supercomplexes with monocarboxylate transporters (MCT) and amino acid transporters such as CD98hc and large neutral amino acid transporter 1 (LAT1), as well as the functional contribution of CD147 in complexes with caveolin-1 and integrins, is discussed. Target validation experiments making use of CD147-directed RNAi and monoclonal antibodies are summarized. Finally, the relevance of CD147 as a target for therapeutic intervention in cancer patients is discussed.