Cluster headache: a review of neuroimaging findings.
Cluster headache: a review of neuroimaging findings.
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DOI：
10.1007/s11916-007-0010-1
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发表时间：
2007-04-01
影响因子：
3.7
通讯作者：
Borsook, David
中科院分区：
文献类型：
--
作者：
DaSilva, Alexandre F M;Goadsby, Peter J;Borsook, David
丛集性头痛被归类为三叉神经自主性头痛，其特征是反复发作的短暂剧烈疼痛，同时伴有自主神经体征。这些临床特征导致了这样的假设，即丛集性头痛的病理生理学涉及中枢神经系统结构，包括下丘脑。在过去的十年中，神经影像学研究已经证实了这种临床衍生的理论，揭示了在体内神经元的变化，位于下丘脑后下部。在丛集性头痛患者中使用各种神经成像技术（功能，生物化学和结构），我们正在改善对大脑在这种疾病中的作用的理解。本文总结了丛集性头痛患者的神经影像学表现，描述了发作和缓解期间以及下丘脑刺激期间发生的神经元变化。
Classified as a trigeminal autonomic cephalalgia, cluster headache is characterized by recurrent short-lived excruciating pain attacks, which are concurrent with autonomic signs. These clinical features have led to the assumption that cluster headache's pathophysiology involves central nervous system structures, including the hypothalamus. In the past decade, neuroimaging studies have confirmed such clinically derived theory by uncovering in vivo neuronal changes located in the inferior posterior hypothalamus. Using a variety of neuro-imaging techniques (functional , biochemical , and structural ) in patients with cluster headache, we are making improvements in our understanding of the role of the brain in this disorder. This article summarizes neuroimaging findings in cluster headache patients, describing neuronal changes that occur during attacks and remission, as well as during hypothalamic stimulation.