Follicle-Stimulating Hormone Secretion in the Female Rat: Cyclic Release Is Dependent on Circulating Androgen
Follicle-Stimulating Hormone Secretion in the Female Rat: Cyclic Release Is Dependent on Circulating Androgen
复制标题
雌性大鼠的卵泡刺激激素分泌：循环释放依赖于循环雄激素
DOI：
10.1126/science.184.4132.75
复制
发表时间：
1974
期刊：
影响因子：
56.9
通讯作者：
R. L. Tomacari
中科院分区：
文献类型：
--
作者：
V. Gay;R. L. Tomacari
在成年周期性雌性大鼠中，静脉注射睾酮抗血清可防止血清促卵泡激素（FSH）的持续增加，这种持续增加通常发生在发情期的清晨。这种处理不能阻止在关键期（发情前期1400 - 2000）发生的血清FSH（和促黄体生成激素）的初始升高，也不能干扰随后的排卵。这些观察结果表明，存在两个独立的机制排卵前FSH释放大鼠和牵连循环睾酮作为刺激持续分泌FSH在发情期。
In adult cyclic female rats, intravenous injections of an antiserum to testosterone prevented the continued increase in serum follicle-stimulating hormone (FSH) which normally occurs during the early morning hours of estrus. This treatment did not prevent the initial increases in serum FSH (and luteinizing hormone) which occur during the critical period (1400 to 2000 of proestrus), nor did it interfere with subsequent ovulation. These observations indicate the existence of two separate mechanisms for preovulatory FSH release in the rat and implicate circulating testosterone as the stimulus for continued secretion of FSH during estrus.