Lysozyme synthesis in osteoclasts.
Lysozyme synthesis in osteoclasts.
复制标题
破骨细胞中溶菌酶的合成。
DOI：
10.1002/jbmr.5650051205
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Kahn,AJ
中科院分区：
文献类型：
--
作者：
Hilliard,TJ;Meadows,G;Kahn,AJ
破骨细胞可能与单核细胞和巨噬细胞直接相关，也可能不直接相关，但众所周知，这些细胞类型有许多共同的特征。(1)在本研究中，我们试图通过评估破骨细胞中溶菌酶的合成来扩大这种比较，溶菌酶是一种已知由单核细胞和巨噬细胞大量产生和分泌的酶。(2，3)我们的数据显示，新鲜分离的鸡破骨细胞和原位破骨细胞含有大量的溶菌酶，相应地，该酶的信使RNA的稳定水平也较高。在体外成熟的不同阶段，骨髓巨噬细胞也有溶菌酶mRNA，但数量大约比破骨细胞少两到四倍。这些观察重申了破骨细胞的单核巨噬细胞的性质，但提出了关于溶菌酶在该细胞中的功能的问题。目前，溶菌酶在破骨细胞活性中的作用尚不清楚。
Osteoclasts may or may not be directly related to monocytes and macrophages, but it is well established that these cell types share a number of features in common.(1)In the present study we sought to extend this comparison by assessing lysozyme synthesis in osteoclasts, an enzyme known to be produced and secreted in large amounts by monocytes and macrophages.(2,3)Our data show that freshly isolated chicken osteoclasts and osteoclasts in situ contain an abundant amount of lysozyme and correspondingly high steady‐state levels of the enzyme's messenger RNA. Marrow macrophages, at various stages of in vitro maturation, also possess lysozyme mRNA but in amounts approximately two to four times lower than osteoclasts. These observations reaffirm the monocyte‐macrophage nature of the osteoclast but raise questions about the function of the lysozyme in this cell. At present, the role of the lysozyme in osteoclast activity remains unexplained.