ALTERED ANGIOARCHITECTURE IN SELECTED AREAS OF BRAINS WITH ALZHEIMERS-DISEASE
ALTERED ANGIOARCHITECTURE IN SELECTED AREAS OF BRAINS WITH ALZHEIMERS-DISEASE
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DOI：
10.1007/bf00294246
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发表时间：
1990-01-01
影响因子：
12.7
通讯作者：
YUSUFALY, Y
中科院分区：
文献类型：
--
作者：
FISCHER, VW;SIDDIQI, A;YUSUFALY, Y
本研究的目的是定性和定量地确定阿尔茨海默病（AD）患者死后脑血管的变化，并将这些发现与一组无脑疾病的个体的脑血管外观进行比较。对来自四个脑区（前额叶（Brodmann区9）、基底前脑、感觉运动区和海马）的脑组织火棉胶切片进行碱性磷酸酶反应，以便于评价血管分布。通过用100平方的显微镜测试网格计数血管交叉点的数量来确定5个切片中的血管密度;以这种方式检查每个切片的10个视野。对16个AD和6个对照脑的分析显示，在AD脑的基底前脑区域和海马中，血管网密度特别地有显著的和统计学上显著的减少。此外，血管在AD大脑表现出广泛的地形变化，如扭结和循环。这些结果表明，血管密度的修改存在于AD脑中具有显着的区域特异性。
It was the aim of this study to determine, qualitatively and quantitatively, alterations in the blood vessels of brains removed postmortem from patients with Alzheimer''s disease (AD), and to compare these findings with the appearance of cerebral blood vessels in a group of individuals without brain disorders. Celloidin sections of brain tissue from four cerebral areas, pre-frontal (Brodmann''s area 9), basal forebrain, sensorimotor, and hippocampus, were subjected to an alkaline phosphatase reaction to facilitate the evaluation of the vascular distribution. The vascular density in five sections was determined by counting the number of vascular intersections with a microscopic test grid of 100 squares; ten fields per section were examined in this manner. Analysis of 16 AD and 6 control brains, showed that there was a striking and statistically significant reduction in the vascular net density specifically in the basal forebrain region and the hippocampus of AD brains. In addition, vessels in the AD brains exhibited extensive topographical changes, such as kinking and looping. These results indicate that modifications in vascular density are present in AD brains with a marked regional specificity.