Placental transfer of perfluorinated compounds is selective - A Norwegian Mother and Child sub-cohort study
Placental transfer of perfluorinated compounds is selective - A Norwegian Mother and Child sub-cohort study
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DOI：
10.1016/j.ijheh.2011.08.011
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发表时间：
2012-02-01
影响因子：
6
通讯作者：
Brunborg, Gunnar
中科院分区：
文献类型：
--
作者：
Gutzkow, Kristine Bjerve;Haug, Line Smastuen;Brunborg, Gunnar
全氟化合物（PFCs）是一大类人造氟化化学品，用于许多消费品和工业应用。全氟化学品在环境中具有持久性、生物累积性和广泛性。动物研究已证实了肝毒性、免疫毒性、发育毒性以及激素效应。我们调查了产前暴露于几种PFCs，并在挪威母亲和儿童队列研究（MoBa）的一个子队列中的123对人类母体和脐带血样本中检测到多达7种不同的PFCs。母体和胎儿的水平显着相关的所有PFC测试与中位PFC浓度之间的30和79%的母体浓度范围内的脐带血，证明胎盘通过。不同的全氟化学品的组成在脐带血和母血之间存在差异，脐带血中短链全氟化学品的比例较高，全氟辛烷磺酸的支链异构体的含量也较高。此外，磺酸盐基团似乎阻碍了转移效率。这表明不同PFC选择性地通过胎盘，因此是特定的胎儿暴露。(C)2011年Elsevier GmbH。All rights reserved.
Perfluorinated compounds (PFCs) comprise a large group of man-made fluorinated chemicals used in a number of consumer products and industrial applications. PFCs have shown to be persistent, bio-accumulative and widespread in the environment. Animal studies have demonstrated hepatotoxicity, immunotoxicity, developmental toxicity as well as hormonal effects. We investigated prenatal exposure to several PFCs and detected up to seven different PFCs in 123 paired samples of human maternal and cord blood, from a subcohort of the Norwegian Mother and Child Cohort Study (MoBa). The maternal and foetal levels were significantly correlated for all PFCs tested with median PFC concentrations in cord blood ranging between 30 and 79% of the maternal concentrations, demonstrating placental passage. The composition of the different PFCs varied between cord and maternal blood, with a higher proportion of shorter chained PFCs together with a higher amount of the branched isomers of perfluorooctane sulfonate (PFOS) in cord blood. Additionally, the sulfonate group seems to impede transfer efficiency. This indicates a selective placental passage of the different PFCs and hence a specific foetal exposure. (C) 2011 Elsevier GmbH. All rights reserved.