Cracking the code of neuronal apoptosis and survival.
Cracking the code of neuronal apoptosis and survival.
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DOI：
10.1038/cddis.2015.309
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发表时间：
2015-11-05
影响因子：
9
通讯作者：
Cavallaro S
中科院分区：
文献类型：
--
作者：
Cavallaro S
神经细胞凋亡和存活是中枢神经系统发育过程中调控细胞命运及其整个成年期内稳态的严格控制过程。一项对小脑颗粒神经元原代培养的新研究发现，在胰岛素样生长因子-1 （Igf1）和垂体腺苷酸环化酶激活多肽（Pacap）对细胞凋亡的拯救过程中，存在共同的转录级联，从而表明细胞存活途径存在高度保守性。
Neuronal apoptosis and survival are tightly controlled processes that regulate cell fate during the development of the central nervous system and its homeostasis throughout adulthood. A new study in primary cultures of cerebellar granule neurons identified common transcriptional cascades during rescue from apoptosis by insulin-like growth factor-1 (Igf1) and pituitary adenylyl cyclase-activating polypeptide (Pacap), thus suggesting the existence of a high degree of conservation of cell survival pathways.