Temporal Changes in Erectile Function and Endothelium-Dependent Relaxing Response of Corpus Cavernosal Smooth Muscle After Ischemia by Ligation of Bilateral Internal Iliac Arteries in the Rabbit
Temporal Changes in Erectile Function and Endothelium-Dependent Relaxing Response of Corpus Cavernosal Smooth Muscle After Ischemia by Ligation of Bilateral Internal Iliac Arteries in the Rabbit
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DOI：
10.1254/jphs.12113sc
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发表时间：
2012-11-01
影响因子：
3.5
通讯作者：
Kimura, Kazunori
中科院分区：
文献类型：
--
作者：
Abe, Yuko;Hotta, Yuji;Kimura, Kazunori
我们的目的是阐明急性阴茎缺血兔海绵体平滑肌（CCSM）松弛功能和勃起功能的变化。对乙酰胆碱（Ach）的舒张反应在缺血后3天无变化。对ACh的反应在1周时显著降低，但在4周时完全恢复。在所有时间点，缺血对硝普钠和电场刺激的反应均无变化。勃起功能的变化与ACh的反应相同。发现CCSM的内皮依赖性舒张反应和勃起功能最初下降，但随后完全改善。
We aimed to elucidate the changes in the relaxation function of corpus cavernosal smooth muscle (CCSM) and erectile function using acute penile ischemic rabbits. Relaxation response to acetylcholine (Ach) was unchanged at 3 days after ischemia. The response to ACh had significantly decreased at 1 week, but had recovered completely at 4 weeks. The reaction to sodium nitroprusside and electrical field stimulation was unchanged by ischemia at all time points. Erectile function was changed in the same manner as the response of ACh. The endothelium-dependent relaxing responses of CCSM and erectile function were found to be initially decreased, but subsequently improved completely.