Potent anti-hepatitis B viral activity and inhibition of bacteriophage T7 RNA polymerase by a "fat" nucleoside and its 5'-triphosphate derivative: synthetic, biochemical, and biological studies of 4,8-diamino-6-imino-6H-1-beta-D-ribofuranosyl-imidazo[4,5-
Potent anti-hepatitis B viral activity and inhibition of bacteriophage T7 RNA polymerase by a "fat" nucleoside and its 5'-triphosphate derivative: synthetic, biochemical, and biological studies of 4,8-diamino-6-imino-6H-1-beta-D-ribofuranosyl-imidazo[4,5-
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“脂肪”核苷及其 5-三磷酸衍生物具有有效的抗乙型肝炎病毒活性并抑制噬菌体 T7 RNA 聚合酶：4,8-二氨基-6-亚氨基-6H-1- 的合成、生化和生物学研究
DOI：
10.1080/15257779908041574
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Hosmane,RS
中科院分区：
文献类型：
--
作者：
Bretner,M;Beckett,D;Hosmane,RS
核苷4，8-diamino-6-imino-6H-1-β-d-ribofuranosylimidazo[4，5-e][1，3]-diazepine，具有较强的体外抗乙肝病毒活性，毒性最小，其5‘-三磷酸衍生物对噬菌体77RNA聚合酶有较强的抑制作用。
The title nucleoside, 4,8-diamino-6-imino-6H-1-β-d-ribofuranosylimidazo[4,5-e][1,3]-diazepine, exhibited potent anti-hepatitis B viral activity with minimum toxicity in vitro, and its 5′-triphosphate derivative strongly inhibited the bacteriophage 77 RNA polymerase.