ENTORHINAL CORTEX OF THE HUMAN, MONKEY, AND RAT - METABOLIC MAP AS REVEALED BY CYTOCHROME-OXIDASE
ENTORHINAL CORTEX OF THE HUMAN, MONKEY, AND RAT - METABOLIC MAP AS REVEALED BY CYTOCHROME-OXIDASE
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DOI：
10.1002/cne.903260310
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发表时间：
1992-12-15
影响因子：
2.5
通讯作者：
WONGRILEY, MTT
中科院分区：
文献类型：
--
作者：
HEVNER, RF;WONGRILEY, MTT
内嗅皮层（EC）是内侧颞叶区域，参与记忆巩固。从以前的研究结果表明，EC的上层可以组织成解剖神经化学模块相关的通路，通过在层II和III的神经元簇。为了研究EC中的代谢模式并寻找所提出的模块的相关性，我们研究了细胞色素氧化酶（CO）在人、猴和大鼠EC中的分布。CO是一种线粒体酶，已被用于研究其他皮质区域的模块。在所有三个物种中，第II-III层中的神经元簇呈深CO反应，而簇之间的大多数神经元簇呈轻度或中度CO反应。然而，一些直接邻近神经元簇的神经元区域也呈暗CO反应性，尤其是在人类中;这些神经元区域包括第I层和第II层的部分。在通过层I-II的切向切片中，深色染色区域形成一致的图案，由与神经元簇相关的部分互连的岛和条纹组成。在来自一个人半球的EC中，存在大约200-250个CO反应层Il岛。EC层以外的I-III也表现出特征性的CO染色强度，但没有证据modularity.Our研究结果表明，CO染色标签不同的车厢有关的神经元簇在上EC层。我们建议，这些隔间可能代表模块的皮层处理，类似于CO标记的模块在一些其他领域的皮层。
The entorhinal cortex (EC) is a medial temporal lobe area involved in memory consolidation. Results from previous studies suggest that the upper layers of the EC may be organized into anatomical-neurochemical modules associated with pathways through the neuron clusters in layers II and III. To study metabolic patterns in the EC and to look for correlates of the proposed modules, we examined the distribution of cytochrome oxidase (CO) in the human, monkey, and rat EC. CO is a mitochondrial enzyme that has been used to study modules in other cortical areas.In all three species, the neuron clusters in layers II-III were darkly CO-reactive, whereas most of the neuropil between clusters was lightly or moderately CO-reactive. However, some neuropil regions directly adjacent to the neuron clusters were also darkly CO-reactive, especially in the human; these neuropil areas included portions of layers I and II. In tangential sections through layers I-II, the areas of dark staining formed a consistent pattern, comprised of partially interconnected islands and stripes associated with the neuron clusters. In the EC from one human hemisphere, approximately 200-250 CO-reactive layer Il islands were present. EC layers other than I-III also showed characteristic CO staining intensities, but no evidence of modularity.Our results indicate that CO staining labels distinct compartments related to the neuron clusters in the upper EC layers. We propose that these compartments may represent modules for cortical processing, analogous to the CO-labeled modules in some other areas of cortex.